TARDBP

GENE INFORMATION

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Gene name

TARDBP (HGNC Symbol)

Synonyms

ALS10, TDP-43

Description

TAR DNA binding protein (HGNC Symbol)

Entrez gene summary

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.22

Chromosome location (bp)

11012344 - 11026420

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000120948 (version 78.38)

Entrez gene

23435

UniProt

Q13148 (UniProt - Evidence at protein level)

neXtProt

NX_Q13148

Antibodypedia

TARDBP antibodies
 

PROTEIN VIEW

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TARDBP-001
 
TARDBP-003
 
TARDBP-004
 
TARDBP-005
 
TARDBP-012
 
TARDBP-013
 
TARDBP-016
 
TARDBP-017
 
TARDBP-019
 
TARDBP-022
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TARDBP-001 ENSP00000240185
ENST00000240185
Q13148
Show all »
Show » Show » 414 44.7 No 0
TARDBP-003 ENSP00000313129
ENST00000315091
B1AKP7
Show all »
Show » Show » 295 33.5 No 0
TARDBP-004 ENSP00000465240
ENST00000473118
K7EJM5
Show all »
Show » Show » 201 22.8 No 0
TARDBP-005 ENSP00000466842
ENST00000476201
K7EN94
Show all »
Show » Show » 276 31.4 No 0
TARDBP-012 ENSP00000482191
ENST00000621790
K7EJM5
Show all »
Show » Show » 304 34.3 No 0
TARDBP-013 ENSP00000484722
ENST00000616545
K7EJM5
Show all »
Show » Show » 301 34.2 No 0
TARDBP-016 ENSP00000480690
ENST00000621715
Show » Show » 243 26.7 No 0
TARDBP-017 ENSP00000481206
ENST00000622057
Show » Show » 200 22.8 No 0
TARDBP-019 ENSP00000479219
ENST00000617172
Show » Show » 212 24 No 0
TARDBP-022 ENSP00000482559
ENST00000610369
Show » Show » 127 14.5 No 0