NPPB

GENE INFORMATION

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Gene name

NPPB

Synonyms

Description

Natriuretic peptide B (HGNC Symbol)

Entrez gene summary

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]

Chromosome

1

Cytoband

p36.22

Chromosome location (bp)

11857464 - 11858931

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000120937 (version 78.38)

Entrez gene

4879

UniProt

P16860 (UniProt - Evidence at protein level)

neXtProt

NX_P16860

Antibodypedia

NPPB antibodies
 

PROTEIN VIEW

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NPPB-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NPPB-001 ENSP00000365651
ENST00000376468
P16860
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