DUSP4 - Gene info - The Human Protein Atlas

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DUSP4

TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	DUSP4 (HGNC Symbol)
Synonyms	HVH2, MKP-2, TYP
Description	Dual specificity phosphatase 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p12
Chromosome location (bp)	29333064 - 29350668
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120875 (version 78.38)
Entrez gene	1846
UniProt	Q13115 (UniProt - Evidence at protein level)
neXtProt	NX_Q13115
Antibodypedia	DUSP4 antibodies

PROTEIN VIEW

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DUSP4-001		DUSP4-002

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
DUSP4-001	ENSP00000240100 ENST00000240100	Q13115 Show all » « Hide Q13115 [Direct mapping] Dual specificity protein phosphatase 4	Show » « Hide Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000165 [MAPK cascade] GO:0000188 [inactivation of MAPK activity] GO:0001706 [endoderm formation] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0008330 [protein tyrosine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051403 [stress-activated MAPK cascade]	394	43	No	0
DUSP4-002	ENSP00000240101 ENST00000240101	Q13115 Show all » « Hide Q13115 [Direct mapping] Dual specificity protein phosphatase 4	Show » « Hide Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000165 [MAPK cascade] GO:0000188 [inactivation of MAPK activity] GO:0001706 [endoderm formation] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0008330 [protein tyrosine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051403 [stress-activated MAPK cascade]	303	33	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.