TNFSF11

GENERAL INFORMATION

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Gene name

TNFSF11

Gene description

Tumor necrosis factor (ligand) superfamily, member 11

Protein class

Cancer-related genes
CD markers
Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lymph node)
GTEx:Tissue enhanced (small intestine, testis)

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic expression in a subset of leukocytes.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA045142 , CAB009193
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lymph node)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (small intestine, testis)

Organ

Expression



GENE INFORMATION

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Gene name

TNFSF11 (HGNC Symbol)

Synonyms

CD254, ODF, OPGL, RANKL, TRANCE

Description

Tumor necrosis factor (ligand) superfamily, member 11 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]

Chromosome

13

Cytoband

q14.11

Chromosome location (bp)

42562736 - 42608013

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000120659 (version 78.38)

Entrez gene

8600

UniProt

O14788 (UniProt - Evidence at protein level)

neXtProt

NX_O14788

Antibodypedia

TNFSF11 antibodies


PROTEIN BROWSER

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ENST00000239849
 
ENST00000358545
 
ENST00000398795
 
ENST00000405262
 
ENST00000544862
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNFSF11-001 ENSP00000381775
ENST00000398795
O14788
Show all »
Show » Show » 317 35.5 No 1
TNFSF11-002 ENSP00000351347
ENST00000358545
O14788
Show all »
Show » Show » 244 27.7 No 0
TNFSF11-201 ENSP00000239849
ENST00000239849
O14788
Show all »
Show » Show » 270 30.5 Yes 0
TNFSF11-202 ENSP00000384042
ENST00000405262
O14788
Show all »
Show » Show » 244 27.7 No 0
TNFSF11-203 ENSP00000444913
ENST00000544862
O14788
Show all »
Show » Show » 244 27.7 No 0