MXI1

GENE INFORMATION

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Gene name

MXI1 (HGNC Symbol)

Synonyms

bHLHc11, MAD2, MXD2, MXI

Description

MAX interactor 1, dimerization protein (HGNC Symbol)

Entrez gene summary

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q25.2

Chromosome location (bp)

110207605 - 110287365

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000119950 (version 78.38)

Entrez gene

4601

UniProt

P50539 (UniProt - Evidence at protein level)

neXtProt

NX_P50539

Antibodypedia

MXI1 antibodies
 

PROTEIN VIEW

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MXI1-004
 
MXI1-005
 
MXI1-006
 
MXI1-008
 
MXI1-009
 
MXI1-010
 
MXI1-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MXI1-004 ENSP00000331152
ENST00000332674
P50539
Show all »
Show » Show » 295 32.8 No 0
MXI1-005 ENSP00000354606
ENST00000361248
P50539
Show all »
Show » Show » 182 20.6 No 0
MXI1-006 ENSP00000239007
ENST00000239007
P50539
Show all »
Show » Show » 228 26.1 No 0
MXI1-008 ENSP00000398981
ENST00000453116
F6U3F6
Show all »
Show » Show » 226 25.3 No 0
MXI1-009 ENSP00000376842
ENST00000393134
B1ANN8
Show all »
Show » Show » 218 24.9 No 0
MXI1-010 ENSP00000407711
ENST00000442296
F6WCI9
Show all »
Show » Show » 118 13.8 No 0
MXI1-011 ENSP00000358625
ENST00000369612
P50539
Show all »
Show » Show » 192 21.8 No 0