KDSR

GENE INFORMATION

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Gene name

KDSR (HGNC Symbol)

Synonyms

DHSR, FVT1, SDR35C1

Description

3-ketodihydrosphingosine reductase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008]

Chromosome

18

Cytoband

q21.33

Chromosome location (bp)

63327726 - 63367510

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000119537 (version 78.38)

Entrez gene

2531

UniProt

Q06136 (UniProt - Evidence at protein level)

neXtProt

NX_Q06136

Antibodypedia

KDSR antibodies
 

PROTEIN VIEW

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KDSR-001
 
KDSR-009
 
KDSR-010
 
KDSR-013
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KDSR-001 ENSP00000385083
ENST00000406396
Q06136
Show all »
Show » Show » 332 36.2 Yes 1
KDSR-009 ENSP00000468203
ENST00000591902
K7ERC8
Show all »
Show » Show » 203 22.6 No 0
KDSR-010 ENSP00000312939
ENST00000326575
Q06136
Show all »
Show » Show » 268 29.2 Yes 1
KDSR-013 ENSP00000467962
ENST00000592327
K7EQS7
Show all »
Show » Show » 155 16.8 Yes 0