TJP2

GENE INFORMATION

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Gene name

TJP2 (HGNC Symbol)

Synonyms

DFNA51, X104, ZO-2, ZO2

Description

Tight junction protein 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Chromosome

9

Cytoband

q21.11

Chromosome location (bp)

69121264 - 69255208

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000119139 (version 78.38)

Entrez gene

9414

UniProt

Q9UDY2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UDY2

Antibodypedia

TJP2 antibodies
 

PROTEIN VIEW

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TJP2-001
 
TJP2-002
 
TJP2-003
 
TJP2-004
 
TJP2-006
 
TJP2-007
 
TJP2-201
 
TJP2-202
 
TJP2-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TJP2-001 ENSP00000402941
ENST00000423935
B1AN86
Show all »
Show » Show » 161 17.9 No 0
TJP2-002 ENSP00000366469
ENST00000377259
B1AN85
Show all »
Show » Show » 101 10.9 No 0
TJP2-003 ENSP00000366453
ENST00000377245
Q9UDY2
Show all »
Show » Show » 1190 134 No 0
TJP2-004 ENSP00000265384
ENST00000265384
Q9UDY2
Show all »
Show » Show » 993 111.7 No 0
TJP2-006 ENSP00000345893
ENST00000348208
Q9UDY2
Show all »
Show » Show » 1043 117.8 No 0
TJP2-007 ENSP00000475926
ENST00000606364
U3KQJ2
Show all »
Show » Show » 134 14.8 No 0
TJP2-201 ENSP00000392178
ENST00000453658
Q9UDY2
Show all »
Show » Show » 1020 115.2 No 0
TJP2-202 ENSP00000442090
ENST00000535702
Q9UDY2
Show all »
Show » Show » 1157 130.4 No 0
TJP2-203 ENSP00000438262
ENST00000539225
Q9UDY2
Show all »
Show » Show » 1221 137.3 No 0