FOXO3

GENERAL INFORMATION

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Gene name

FOXO3

Gene description

Forkhead box O3

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
CAB004074
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

FOXO3 (HGNC Symbol)

Synonyms

AF6q21, FKHRL1, FOXO2, FOXO3A

Description

Forkhead box O3 (HGNC Symbol)

Entrez gene summary

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

q21

Chromosome location (bp)

108559835 - 108684774

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118689 (version 78.38)

Entrez gene

2309

UniProt

O43524 (UniProt - Evidence at protein level)

neXtProt

NX_O43524

Antibodypedia

FOXO3 antibodies


PROTEIN BROWSER

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ENST00000343882
 
ENST00000406360
 
ENST00000540898
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FOXO3-001 ENSP00000339527
ENST00000343882
O43524
Show all »
Show » Show » 673 71.3 No 0
FOXO3-201 ENSP00000385824
ENST00000406360
O43524
Show all »
Show » Show » 673 71.3 No 0
FOXO3-202 ENSP00000446316
ENST00000540898
O43524
Show all »
Show » Show » 453 48.4 No 0