SGK1 - Gene info - The Human Protein Atlas

Gene name

SGK1 (HGNC Symbol)

Synonyms

SGK

Description

Serum/glucocorticoid regulated kinase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

Chromosome

Cytoband

q23.2

Chromosome location (bp)

134169246 - 134318112

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118515 (version 78.38)

Entrez gene

6446

UniProt

O00141 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SGK1-001

ENSP00000356832
ENST00000367858

O00141
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O00141 [Direct mapping]
Serine/threonine-protein kinase Sgk1
B7Z1G1 [Target identity:54%; Query identity:100%]
cDNA FLJ52914, highly similar to Serine/threonine-protein kinase Sgk1 {ECO:0000313|EMBL:BAH11497.1}
E9PJN2 [Target identity:27%; Query identity:100%]
Serine/threonine-protein kinase Sgk1 {ECO:0000313|Ensembl:ENSP00000435577}
E9PP33 [Target identity:11%; Query identity:100%]
Serine/threonine-protein kinase Sgk1 {ECO:0000313|Ensembl:ENSP00000436470}

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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006814 [sodium ion transport]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007616 [long-term memory]
GO:0008217 [regulation of blood pressure]
GO:0015459 [potassium channel regulator activity]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0030334 [regulation of cell migration]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035091 [phosphatidylinositol binding]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0050790 [regulation of catalytic activity]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0055085 [transmembrane transport]
GO:0060453 [regulation of gastric acid secretion]
GO:0070294 [renal sodium ion absorption]

526

59.9

SGK1-002

ENSP00000435724
ENST00000524929

Q7Z3I4
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Q7Z3I4 [Target identity:100%; Query identity:100%]
Putative uncharacterized protein DKFZp686H1615 {ECO:0000313|EMBL:CAD97879.1}; Serine/threonine-protein kinase Sgk1 {ECO:0000313|Ensembl:ENSP00000435724}
E9PP33 [Target identity:39%; Query identity:100%]
Serine/threonine-protein kinase Sgk1 {ECO:0000313|Ensembl:ENSP00000436470}

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Predicted intracellular proteins
Cancer-related genes
Mutated cancer genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

153

17.5

SGK1-004

ENSP00000431705
ENST00000460769

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Predicted intracellular proteins
Cancer-related genes
Mutated cancer genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

5.8

SGK1-009

ENSP00000237305
ENST00000237305

O00141
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O00141 [Direct mapping]
Serine/threonine-protein kinase Sgk1
B7Z1G1 [Target identity:66%; Query identity:100%]
cDNA FLJ52914, highly similar to Serine/threonine-protein kinase Sgk1 {ECO:0000313|EMBL:BAH11497.1}
Q6AW81 [Target identity:11%; Query identity:100%]
Putative uncharacterized protein DKFZp686M0890 {ECO:0000313|EMBL:CAH10381.1}
Q8IZV4 [Target identity:5%; Query identity:100%]
Serum and glucocorticoid regulated kinase {ECO:0000313|EMBL:AAN40971.1}

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GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006814 [sodium ion transport]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0007616 [long-term memory]
GO:0008217 [regulation of blood pressure]
GO:0015459 [potassium channel regulator activity]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0030334 [regulation of cell migration]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035091 [phosphatidylinositol binding]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0050790 [regulation of catalytic activity]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0055085 [transmembrane transport]
GO:0060453 [regulation of gastric acid secretion]
GO:0070294 [renal sodium ion absorption]

431

48.9

SGK1-010

ENSP00000396242
ENST00000413996

O00141
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O00141 [Direct mapping]
Serine/threonine-protein kinase Sgk1
B7Z1G1 [Target identity:64%; Query identity:100%]
cDNA FLJ52914, highly similar to Serine/threonine-protein kinase Sgk1 {ECO:0000313|EMBL:BAH11497.1}
R4I3I2 [Target identity:15%; Query identity:100%]
Sgk1 variant i3 {ECO:0000313|EMBL:AFJ04414.1}

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GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006814 [sodium ion transport]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0007616 [long-term memory]
GO:0008217 [regulation of blood pressure]
GO:0015459 [potassium channel regulator activity]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0030334 [regulation of cell migration]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035091 [phosphatidylinositol binding]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0050790 [regulation of catalytic activity]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0055085 [transmembrane transport]
GO:0060453 [regulation of gastric acid secretion]
GO:0070294 [renal sodium ion absorption]

445

50.6

SGK1-011

ENSP00000356831
ENST00000367857

O00141
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O00141 [Direct mapping]
Serine/threonine-protein kinase Sgk1
B7Z1G1 [Target identity:68%; Query identity:100%]
cDNA FLJ52914, highly similar to Serine/threonine-protein kinase Sgk1 {ECO:0000313|EMBL:BAH11497.1}

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GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006814 [sodium ion transport]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0007616 [long-term memory]
GO:0008217 [regulation of blood pressure]
GO:0015459 [potassium channel regulator activity]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0030334 [regulation of cell migration]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035091 [phosphatidylinositol binding]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0050790 [regulation of catalytic activity]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0055085 [transmembrane transport]
GO:0060453 [regulation of gastric acid secretion]
GO:0070294 [renal sodium ion absorption]

421

47.9

SGK1-017

ENSP00000434450
ENST00000528577

O00141
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O00141 [Direct mapping]
Serine/threonine-protein kinase Sgk1
B7Z1G1 [Target identity:62%; Query identity:100%]
cDNA FLJ52914, highly similar to Serine/threonine-protein kinase Sgk1 {ECO:0000313|EMBL:BAH11497.1}

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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006814 [sodium ion transport]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0007616 [long-term memory]
GO:0008217 [regulation of blood pressure]
GO:0015459 [potassium channel regulator activity]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0030334 [regulation of cell migration]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035091 [phosphatidylinositol binding]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0050790 [regulation of catalytic activity]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0055085 [transmembrane transport]
GO:0060453 [regulation of gastric acid secretion]
GO:0070294 [renal sodium ion absorption]

459

52.1

SGK1-018

ENSP00000434302
ENST00000475719

E9PR89
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E9PR89 [Target identity:100%; Query identity:100%]
Serine/threonine-protein kinase Sgk1 {ECO:0000313|Ensembl:ENSP00000434302}
Q6AW81 [Target identity:12%; Query identity:100%]
Putative uncharacterized protein DKFZp686M0890 {ECO:0000313|EMBL:CAH10381.1}
Q8IZV4 [Target identity:6%; Query identity:100%]
Serum and glucocorticoid regulated kinase {ECO:0000313|EMBL:AAN40971.1}

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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0035091 [phosphatidylinositol binding]

387

43.8

SGK1-020

ENSP00000436470
ENST00000533224

E9PP33
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E9PP33 [Target identity:100%; Query identity:100%]
Serine/threonine-protein kinase Sgk1 {ECO:0000313|Ensembl:ENSP00000436470}

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Predicted intracellular proteins
Cancer-related genes
Mutated cancer genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

6.9

SGK1-021

ENSP00000435577
ENST00000461976

E9PJN2
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E9PJN2 [Target identity:100%; Query identity:100%]
Serine/threonine-protein kinase Sgk1 {ECO:0000313|Ensembl:ENSP00000435577}

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Predicted intracellular proteins
Cancer-related genes
Mutated cancer genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0035091 [phosphatidylinositol binding]

144

16.1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.