B4GALT6

GENE INFORMATION

? »

Gene name

B4GALT6 (HGNC Symbol)

Synonyms

beta4GalT-VI

Description

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 (HGNC Symbol)

Entrez gene summary

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Jul 2008]

Chromosome

18

Cytoband

q12.1

Chromosome location (bp)

31622247 - 31685836

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118276 (version 78.38)

Entrez gene

9331

UniProt

Q9UBX8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UBX8

Antibodypedia

B4GALT6 antibodies
 

PROTEIN VIEW

? »
 
 
 
B4GALT6-001
 
B4GALT6-002
 
B4GALT6-003
 
B4GALT6-005
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

B4GALT6-001 ENSP00000306459
ENST00000306851
Q9UBX8
Show all »
Show » Show » 382 44.9 Yes 0
B4GALT6-002 ENSP00000463961
ENST00000579372
J3QQY9
Show all »
Show » Show » 72 8.4 No 0
B4GALT6-003 ENSP00000237019
ENST00000237019
G3XA83
Show all »
Show » Show » 343 40.5 Yes 0
B4GALT6-005 ENSP00000372613
ENST00000383131
Q9UBX8
Show all »
Show » Show » 343 40.1 Yes 0