PADI2

GENE INFORMATION

? »

Gene name

PADI2 (HGNC Symbol)

Synonyms

KIAA0994, PDI2

Description

Peptidyl arginine deiminase, type II (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.13

Chromosome location (bp)

17066761 - 17119435

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000117115 (version 78.38)

Entrez gene

11240

UniProt

Q9Y2J8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y2J8

Antibodypedia

PADI2 antibodies
 

PROTEIN VIEW

? »
 
 
 
PADI2-001
 
PADI2-004
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PADI2-001 ENSP00000364635
ENST00000375486
Q9Y2J8
Show all »
Show » Show » 665 75.6 No 0
PADI2-004 ENSP00000364630
ENST00000375481
Q9Y2J8
Show all »
Show » Show » 437 49.3 No 0