NR5A2 - Gene info - The Human Protein Atlas

Gene name

NR5A2 (HGNC Symbol)

Synonyms

B1F2, FTF, FTZ-F1, FTZ-F1beta, hB1F, hB1F-2, LRH-1

Description

Nuclear receptor subfamily 5, group A, member 2 (HGNC Symbol)

Entrez gene summary

Chromosome

Cytoband

q32.1

Chromosome location (bp)

200027602 - 200177424

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116833 (version 78.38)

Entrez gene

2494

UniProt

O00482 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NR5A2-001

ENSP00000356331
ENST00000367362

O00482
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O00482 [Direct mapping]
Nuclear receptor subfamily 5 group A member 2
Q8WY08 [Target identity:3%; Query identity:100%]
Nuclear receptor NR5A2 {ECO:0000313|EMBL:AAL37171.1}

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Nuclear receptors
Predicted intracellular proteins
Transcription factors
Zinc-coordinating DNA-binding domains

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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008206 [bile acid metabolic process]
GO:0008270 [zinc ion binding]
GO:0009790 [embryo development]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031018 [endocrine pancreas development]
GO:0042127 [regulation of cell proliferation]
GO:0042592 [homeostatic process]
GO:0042632 [cholesterol homeostasis]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]

541

61.3

NR5A2-003

ENSP00000236914
ENST00000236914

O00482
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O00482 [Direct mapping]
Nuclear receptor subfamily 5 group A member 2
F1D8R9 [Target identity:100%; Query identity:100%]
Liver nuclear receptor homolog-1 variant 2 {ECO:0000313|EMBL:ADZ17368.1}
Q8WY08 [Target identity:4%; Query identity:100%]
Nuclear receptor NR5A2 {ECO:0000313|EMBL:AAL37171.1}

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Nuclear receptors
Predicted intracellular proteins
Transcription factors
Zinc-coordinating DNA-binding domains

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GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0009790 [embryo development]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031018 [endocrine pancreas development]
GO:0042592 [homeostatic process]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045893 [positive regulation of transcription, DNA-templated]

495

56.5

NR5A2-004

ENSP00000414888
ENST00000447034

Q9Y5V6
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Q9Y5V6 [Target identity:98%; Query identity:100%]
Hepatocytic transcription factor hB1F-3 {ECO:0000313|EMBL:AAD26566.1}; Nuclear receptor subfamily 5, group A, member 2, isoform CRA_c {ECO:0000313|EMBL:EAW91307.1}

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Predicted intracellular proteins

7.5

NR5A2-005

ENSP00000356326
ENST00000367357

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THUMBUP predicted membrane proteins
Predicted intracellular proteins

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GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043565 [sequence-specific DNA binding]

377

NR5A2-201

ENSP00000439116
ENST00000544748

O00482
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O00482 [Direct mapping]
Nuclear receptor subfamily 5 group A member 2

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Nuclear receptors
Predicted intracellular proteins
Transcription factors
Zinc-coordinating DNA-binding domains

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469

53.7

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.