LEPR

GENE INFORMATION

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Gene name

LEPR (HGNC Symbol)

Synonyms

CD295, OBR

Description

Leptin receptor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]

Chromosome

1

Cytoband

p31.3

Chromosome location (bp)

65420652 - 65641559

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116678 (version 78.38)

Entrez gene

3953

UniProt

P48357 (UniProt - Evidence at protein level)

neXtProt

NX_P48357

Antibodypedia

LEPR antibodies
 

PROTEIN VIEW

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LEPR-001
 
LEPR-002
 
LEPR-003
 
LEPR-005
 
LEPR-201
 
LEPR-202
 
LEPR-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LEPR-001 ENSP00000330393
ENST00000349533
P48357
Show all »
Show » Show » 1165 132.5 No 2
LEPR-002 ENSP00000360099
ENST00000371060
P48357
Show all »
Show » Show » 896 102.5 No 2
LEPR-003 ENSP00000360098
ENST00000371059
P48357
Show all »
Show » Show » 958 109.4 No 2
LEPR-005 ENSP00000360097
ENST00000371058
P48357
Show all »
Show » Show » 906 103.5 No 2
LEPR-201 ENSP00000340884
ENST00000344610
P48357
Show all »
Show » Show » 906 103.5 No 2
LEPR-202 ENSP00000384025
ENST00000406510
A2RRQ4
Show all »
Show » 232 25.9 No 0
LEPR-203 ENSP00000483390
ENST00000616738
P48357
Show all »
Show » Show » 896 102.5 No 2