PARK7

GENERAL INFORMATION

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Gene name

PARK7

Gene description

Parkinson protein 7

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA004190 , CAB005870
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PARK7 (HGNC Symbol)

Synonyms

DJ-1, DJ1

Description

Parkinson protein 7 (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.23

Chromosome location (bp)

7954291 - 7985505

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116288 (version 78.38)

Entrez gene

11315

UniProt

Q99497 (UniProt - Evidence at protein level)

neXtProt

NX_Q99497

Antibodypedia

PARK7 antibodies


PROTEIN BROWSER

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ENST00000338639
 
ENST00000377488
 
ENST00000377491
 
ENST00000377493
 
ENST00000469225
 
ENST00000493373
 
ENST00000493678
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PARK7-001 ENSP00000418770
ENST00000493678
Q99497
Show all »
Show » Show » 189 19.9 No 0
PARK7-002 ENSP00000340278
ENST00000338639
Q99497
Show all »
Show » Show » 189 19.9 No 0
PARK7-003 ENSP00000466242
ENST00000377493
K7ELW0
Show all »
Show » 169 17.9 No 0
PARK7-004 ENSP00000465404
ENST00000493373
Q99497
Show all »
Show » Show » 189 19.9 No 0
PARK7-005 ENSP00000366711
ENST00000377491
Q99497
Show all »
Show » Show » 189 19.9 No 0
PARK7-006 ENSP00000366708
ENST00000377488
Q99497
Show all »
Show » Show » 189 19.9 No 0
PARK7-010 ENSP00000466756
ENST00000469225
K7EN27
Show all »
Show » 160 17 No 0