PAPPA2

GENE INFORMATION

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Gene name

PAPPA2 (HGNC Symbol)

Synonyms

PAPP-A2, PAPPE, PLAC3

Description

Pappalysin 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Chromosome

1

Cytoband

q25.2

Chromosome location (bp)

176463171 - 176845605

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116183 (version 78.38)

Entrez gene

60676

UniProt

Q9BXP8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BXP8

Antibodypedia

PAPPA2 antibodies
 

PROTEIN VIEW

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PAPPA2-001
 
PAPPA2-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PAPPA2-001 ENSP00000356634
ENST00000367662
Q9BXP8
Show all »
Show » Show » 1791 198.5 Yes 0
PAPPA2-002 ENSP00000356633
ENST00000367661
Q9BXP8
Show all »
Show » Show » 827 92.1 Yes 1