Tissue expression of NFE2L2 - Summary - The Human Protein Atlas

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NFE2L2

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	NFE2L2
Gene description	Nuclear factor, erythroid 2-like 2
Protein class	Cancer-related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear and cytoplasmic expression.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Supportive based on 2 antibodies. HPA002990 , CAB020317
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	NFE2L2 (HGNC Symbol)
Synonyms	NRF2
Description	Nuclear factor, erythroid 2-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Chromosome	2
Cytoband	q31.2
Chromosome location (bp)	177227595 - 177392697
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116044 (version 78.38)
Entrez gene	4780
UniProt	Q16236 (UniProt - Evidence at protein level)
neXtProt	NX_Q16236
Antibodypedia	NFE2L2 antibodies

PROTEIN BROWSER

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ENST00000397062		ENST00000397063		ENST00000421929		ENST00000423513		ENST00000430047		ENST00000446151		ENST00000448782		ENST00000449627		ENST00000458603		ENST00000464747		ENST00000586532		ENST00000588123

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
NFE2L2-001	ENSP00000380252 ENST00000397062	Q16236 Show all » « Hide Q16236 [Direct mapping] Nuclear factor erythroid 2-related factor 2 C9J1A8 [Target identity:46%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000400073} C9J0Y1 [Target identity:38%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000412191} K7ER33 [Target identity:24%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000468089} Q9BZF8 [Target identity:4%; Query identity:100%] NF-E2-related factor 2 {ECO:0000313\|EMBL:AAK01657.1}	Show » « Hide Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001205 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001221 [transcription cofactor binding] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0010499 [proteasomal ubiquitin-independent protein catabolic process] GO:0010628 [positive regulation of gene expression] GO:0016567 [protein ubiquitination] GO:0019904 [protein domain specific binding] GO:0030194 [positive regulation of blood coagulation] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0034599 [cellular response to oxidative stress] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0045995 [regulation of embryonic development] GO:0060548 [negative regulation of cell death] GO:0070301 [cellular response to hydrogen peroxide] GO:0071356 [cellular response to tumor necrosis factor] GO:0071499 [cellular response to laminar fluid shear stress] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:2000121 [regulation of removal of superoxide radicals] GO:2000352 [negative regulation of endothelial cell apoptotic process] GO:2000379 [positive regulation of reactive oxygen species metabolic process]	605	67.8	No
NFE2L2-002	ENSP00000380253 ENST00000397063	Q16236 Show all » « Hide Q16236 [Direct mapping] Nuclear factor erythroid 2-related factor 2 C9J1A8 [Target identity:47%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000400073} C9J0Y1 [Target identity:39%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000412191} K7ER33 [Target identity:24%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000468089}	Show » « Hide Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0010499 [proteasomal ubiquitin-independent protein catabolic process] GO:0010628 [positive regulation of gene expression] GO:0016567 [protein ubiquitination] GO:0019904 [protein domain specific binding] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0070301 [cellular response to hydrogen peroxide] GO:0071356 [cellular response to tumor necrosis factor] GO:0071499 [cellular response to laminar fluid shear stress] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:2000352 [negative regulation of endothelial cell apoptotic process]	589	66.1	No
NFE2L2-003	ENSP00000467401 ENST00000464747	Q16236 Show all » « Hide Q16236 [Direct mapping] Nuclear factor erythroid 2-related factor 2 C9J1A8 [Target identity:47%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000400073} C9J0Y1 [Target identity:39%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000412191} K7ER33 [Target identity:24%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000468089}	Show » « Hide Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0010499 [proteasomal ubiquitin-independent protein catabolic process] GO:0010628 [positive regulation of gene expression] GO:0016567 [protein ubiquitination] GO:0019904 [protein domain specific binding] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0070301 [cellular response to hydrogen peroxide] GO:0071356 [cellular response to tumor necrosis factor] GO:0071499 [cellular response to laminar fluid shear stress] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:2000352 [negative regulation of endothelial cell apoptotic process]	589	66.1	No
NFE2L2-006	ENSP00000410015 ENST00000423513	C9JFL6 Show all » « Hide C9JFL6 [Target identity:100%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000410015}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)		141	16.9	No
NFE2L2-008	ENSP00000411575 ENST00000446151	Q16236 Show all » « Hide Q16236 [Direct mapping] Nuclear factor erythroid 2-related factor 2	Show » « Hide Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0010499 [proteasomal ubiquitin-independent protein catabolic process] GO:0010628 [positive regulation of gene expression] GO:0016567 [protein ubiquitination] GO:0019904 [protein domain specific binding] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0070301 [cellular response to hydrogen peroxide] GO:0071356 [cellular response to tumor necrosis factor] GO:0071499 [cellular response to laminar fluid shear stress] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:2000352 [negative regulation of endothelial cell apoptotic process]	582	65.4	No
NFE2L2-009	ENSP00000412191 ENST00000421929	C9J0Y1 Show all » « Hide C9J0Y1 [Target identity:100%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000412191} K7ER33 [Target identity:62%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000468089}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005886 [plasma membrane]	234	26.7	No
NFE2L2-010	ENSP00000391291 ENST00000430047	C9J3K4 Show all » « Hide C9J3K4 [Target identity:100%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000391291}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)		68	7.6	No
NFE2L2-012	ENSP00000391590 ENST00000449627	C9JBM0 Show all » « Hide C9JBM0 [Target identity:100%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000391590}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding]	265	30.2	No
NFE2L2-013	ENSP00000400073 ENST00000448782	C9J1A8 Show all » « Hide C9J1A8 [Target identity:100%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000400073} C9J0Y1 [Target identity:83%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000412191} K7ER33 [Target identity:52%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000468089}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005886 [plasma membrane]	280	31.7	No
NFE2L2-014	ENSP00000416308 ENST00000458603	H7C498 Show all » « Hide H7C498 [Target identity:100%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000416308}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)		47	5.4	No
NFE2L2-015	ENSP00000468089 ENST00000588123	K7ER33 Show all » « Hide K7ER33 [Target identity:100%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000468089}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)		146	16.9	No
NFE2L2-016	ENSP00000464920 ENST00000586532	K7EIW5 Show all » « Hide K7EIW5 [Target identity:100%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000464920} C9J0Y1 [Target identity:88%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000412191} K7ER33 [Target identity:55%; Query identity:100%] Nuclear factor erythroid 2-related factor 2 {ECO:0000313\|Ensembl:ENSP00000468089}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005886 [plasma membrane]	265	30.1	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx