SOS1 - Gene info - The Human Protein Atlas

Gene name

SOS1 (HGNC Symbol)

Synonyms

GF1, GINGF, HGF

Description

Son of sevenless homolog 1 (Drosophila) (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

p22.1

Chromosome location (bp)

38981396 - 39124345

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115904 (version 78.38)

Entrez gene

6654

UniProt

Q07889 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOS1-001

ENSP00000387784
ENST00000426016

Q07889
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Q07889 [Direct mapping]
Son of sevenless homolog 1
Q53SF8 [Target identity:97%; Query identity:100%]
Putative uncharacterized protein SOS1 {ECO:0000313|EMBL:AAX93186.1}
C9K0N6 [Target identity:7%; Query identity:100%]
Son of sevenless homolog 1 {ECO:0000313|Ensembl:ENSP00000393899}
Q9UKX9 [Target identity:2%; Query identity:100%]
Putative uncharacterized protein SOS1 {ECO:0000313|EMBL:AAY24202.1}; SOS1 {ECO:0000313|EMBL:AAF04460.1}

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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0003677 [DNA binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005100 [Rho GTPase activator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014069 [postsynaptic density]
GO:0017124 [SH3 domain binding]
GO:0030168 [platelet activation]
GO:0032320 [positive regulation of Ras GTPase activity]
GO:0032321 [positive regulation of Rho GTPase activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]

1333

152.5

SOS1-003

ENSP00000378479
ENST00000395038

G5E9C8
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G5E9C8 [Target identity:100%; Query identity:100%]
Son of sevenless homolog 1 {ECO:0000313|Ensembl:ENSP00000378479}; Son of sevenless homolog 1 (Drosophila), isoform CRA_d {ECO:0000313|EMBL:EAX00353.1}
Q59GG9 [Target identity:74%; Query identity:100%]
Son of sevenless homolog 1 variant {ECO:0000313|EMBL:BAD92377.1}
C9K0N6 [Target identity:7%; Query identity:100%]
Son of sevenless homolog 1 {ECO:0000313|Ensembl:ENSP00000393899}
Q9UKX9 [Target identity:2%; Query identity:100%]
Putative uncharacterized protein SOS1 {ECO:0000313|EMBL:AAY24202.1}; SOS1 {ECO:0000313|EMBL:AAF04460.1}

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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0003677 [DNA binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
GO:0032321 [positive regulation of Rho GTPase activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0046982 [protein heterodimerization activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]

1318

150.9

SOS1-004

ENSP00000393899
ENST00000451331

C9K0N6
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C9K0N6 [Target identity:100%; Query identity:100%]
Son of sevenless homolog 1 {ECO:0000313|Ensembl:ENSP00000393899}

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Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
Mutated cancer genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0003677 [DNA binding]
GO:0046982 [protein heterodimerization activity]

102

11.8

SOS1-201

ENSP00000384675
ENST00000402219

Q07889
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Show » « Hide

GO:0003677 [DNA binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005100 [Rho GTPase activator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0030168 [platelet activation]
GO:0032320 [positive regulation of Ras GTPase activity]
GO:0032321 [positive regulation of Rho GTPase activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]

1333

152.5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.