CCDC88A

GENE INFORMATION

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Gene name

CCDC88A (HGNC Symbol)

Synonyms

APE, FLJ10392, GIV, GRDN, HkRP1, KIAA1212

Description

Coiled-coil domain containing 88A (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Chromosome

2

Cytoband

p16.1

Chromosome location (bp)

55287842 - 55419921

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115355 (version 78.38)

Entrez gene

55704

UniProt

Q3V6T2 (UniProt - Evidence at protein level)

neXtProt

NX_Q3V6T2

Antibodypedia

CCDC88A antibodies
 

PROTEIN VIEW

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CCDC88A-001
 
CCDC88A-002
 
CCDC88A-003
 
CCDC88A-005
 
CCDC88A-006
 
CCDC88A-008
 
CCDC88A-009
 
CCDC88A-201
 
CCDC88A-202
 
CCDC88A-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCDC88A-001 ENSP00000263630
ENST00000263630
Q3V6T2
Show all »
Show » Show » 1843 212.6 No 0
CCDC88A-002 ENSP00000338728
ENST00000336838
Q3V6T2
Show all »
Show » Show » 1870 216 No 0
CCDC88A-003 ENSP00000413401
ENST00000444458
B3KW94
Show all »
Show » 374 41 No 0
CCDC88A-005 ENSP00000405080
ENST00000426576
H7C2C6
Show all »
Show » Show » 1202 136.6 No 0
CCDC88A-006 ENSP00000390012
ENST00000412148
H0Y470
Show all »
Show » Show » 888 100.6 No 0
CCDC88A-008 ENSP00000415267
ENST00000456975
Show » 737 83.5 No 0
CCDC88A-009 ENSP00000399237
ENST00000430086
C9J225
Show all »
Show » Show » 147 17.1 No 0
CCDC88A-201 ENSP00000404431
ENST00000413716
Q3V6T2
Show all »
Show » Show » 1796 207.8 No 0
CCDC88A-202 ENSP00000410608
ENST00000436346
Q3V6T2
Show all »
Show » Show » 1871 216 No 0
CCDC88A-203 ENSP00000480931
ENST00000621814
C9J225
Show all »
Show » Show » 741 87.3 No 0