PSMD14

GENERAL INFORMATION

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Gene name

PSMD14

Gene description

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear immunoreactivity, accompanied with cytoplasmic staining of weaker intensity, was observed in neuronal cells, trophoblastic cells and in few glandular epithelia. Extracellular material and endothelial cells were distinctly stained. Remaining normal tissues were in general weakly positive.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA002114
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PSMD14 (HGNC Symbol)

Synonyms

pad1, POH1, Rpn11

Description

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 (HGNC Symbol)

Entrez gene summary

This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]

Chromosome

2

Cytoband

q24.2

Chromosome location (bp)

161308038 - 161411717

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115233 (version 78.38)

Entrez gene

10213

UniProt

O00487 (UniProt - Evidence at protein level)

neXtProt

NX_O00487

Antibodypedia

PSMD14 antibodies


PROTEIN BROWSER

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ENST00000409682
 
ENST00000437630
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMD14-001 ENSP00000386541
ENST00000409682
O00487
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Show » Show » 310 34.6 No 0
PSMD14-002 ENSP00000399311
ENST00000437630
C9JW37
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Show » Show » 84 8.8 No 0