TNNC1

GENE INFORMATION

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Gene name

TNNC1 (HGNC Symbol)

Synonyms

TNNC

Description

Troponin C type 1 (slow) (HGNC Symbol)

Entrez gene summary

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]

Chromosome

3

Cytoband

p21.1

Chromosome location (bp)

52451102 - 52454070

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114854 (version 78.38)

Entrez gene

7134

UniProt

P63316 (UniProt - Evidence at protein level)

neXtProt

NX_P63316

Antibodypedia

TNNC1 antibodies
 

PROTEIN VIEW

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TNNC1-001
 
TNNC1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNNC1-001 ENSP00000232975
ENST00000232975
P63316
Show all »
Show » Show » 161 18.4 No 0
TNNC1-002 ENSP00000420596
ENST00000496590
C9JDI3
Show all »
Show » Show » 99 11.4 No 0