UMPS

GENE INFORMATION

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Gene name

UMPS

Synonyms

Description

Uridine monophosphate synthetase (HGNC Symbol)

Entrez gene summary

This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Chromosome

3

Cytoband

q21.2

Chromosome location (bp)

124730366 - 124745193

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114491 (version 78.38)

Entrez gene

7372

UniProt

P11172 (UniProt - Evidence at protein level)

neXtProt

NX_P11172

Antibodypedia

UMPS antibodies
 

PROTEIN VIEW

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UMPS-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UMPS-001 ENSP00000232607
ENST00000232607
P11172
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