VEGFA

GENE INFORMATION

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Gene name

VEGFA (HGNC Symbol)

Synonyms

VEGF, VEGF-A, VPF

Description

Vascular endothelial growth factor A (HGNC Symbol)

Entrez gene summary

This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.1

Chromosome location (bp)

43770184 - 43786487

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112715 (version 78.38)

Entrez gene

7422

UniProt

P15692 (UniProt - Evidence at protein level)

neXtProt

NX_P15692

Antibodypedia

VEGFA antibodies
 

PROTEIN VIEW

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 « 
 
VEGFA-001
 
VEGFA-002
 
VEGFA-003
 
VEGFA-004
 
VEGFA-009
 
VEGFA-011
 
VEGFA-012
 
VEGFA-013
 
VEGFA-014
 
VEGFA-015
 
VEGFA-016
 
VEGFA-018
 
VEGFA-019
 
VEGFA-020
 
VEGFA-021
 
VEGFA-022
 
VEGFA-023
 
VEGFA-024
 
VEGFA-025
 
VEGFA-201
 
VEGFA-202
 
VEGFA-203
 
VEGFA-204
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VEGFA-001 ENSP00000361137
ENST00000372067
H3BLW8
Show all »
Show » Show » 371 40.7 No 0
VEGFA-002 ENSP00000361134
ENST00000372064
Q9UNS8
Show all »
Show » Show » 327 35.6 No 0
VEGFA-003 ENSP00000388465
ENST00000425836
A0A024RD37
Show all »
Show » Show » 395 43.6 No 0
VEGFA-004 ENSP00000361125
ENST00000372055
J3KPA4
Show all »
Show » Show » 412 45.4 No 0
VEGFA-009 ENSP00000230480
ENST00000230480
A2A2V4
Show all »
Show » Show » 163 19 No 0
VEGFA-011 ENSP00000317598
ENST00000324450
Q9UNS8
Show all »
Show » Show » 317 34.4 No 0
VEGFA-012 ENSP00000389864
ENST00000413642
Q9UNS8
Show all »
Show » Show » 389 42.8 No 0
VEGFA-013 ENSP00000421561
ENST00000482630
Q9UNS8
Show all »
Show » Show » 371 40.7 No 0
VEGFA-014 ENSP00000388663
ENST00000417285
Q9UNS8
Show all »
Show » Show » 354 38.6 No 0
VEGFA-015 ENSP00000430594
ENST00000519767
Q9UNS8
Show all »
Show » Show » 323 35.3 No 0
VEGFA-016 ENSP00000429592
ENST00000520265
H0YBI8
Show all »
Show » Show » 111 12.8 No 0
VEGFA-018 ENSP00000429643
ENST00000523950
P15692
Show all »
Show » Show » 191 22.3 Yes 0
VEGFA-019 ENSP00000361148
ENST00000372077
P15692
Show all »
Show » Show » 147 17.2 Yes 0
VEGFA-020 ENSP00000428321
ENST00000520948
P15692
Show all »
Show » Show » 215 25.2 Yes 0
VEGFA-021 ENSP00000430479
ENST00000523873
P15692
Show all »
Show » Show » 232 27 Yes 0
VEGFA-022 ENSP00000409911
ENST00000457104
P15692
Show all »
Show » Show » 137 16 Yes 0
VEGFA-023 ENSP00000430829
ENST00000518689
P15692
Show all »
Show » Show » 209 24.4 Yes 0
VEGFA-024 ENSP00000430002
ENST00000518824
P15692
Show all »
Show » Show » 191 22.3 Yes 0
VEGFA-025 ENSP00000429008
ENST00000523125
P15692
Show all »
Show » Show » 174 20.2 Yes 0
VEGFA-201 ENSP00000478570
ENST00000611736
J3KPA4
Show all »
Show » Show » 412 45.4 No 0
VEGFA-202 ENSP00000478034
ENST00000615393
Q9UNS8
Show all »
Show » Show » 327 35.6 No 0
VEGFA-203 ENSP00000484284
ENST00000617771
Q9UNS8
Show all »
Show » Show » 317 34.4 No 0
VEGFA-204 ENSP00000483241
ENST00000621747
H3BLW8
Show all »
Show » Show » 371 40.7 No 0