E2F3

GENE INFORMATION

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Gene name

E2F3

Synonyms

Description

E2F transcription factor 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Chromosome

6

Cytoband

p22.3

Chromosome location (bp)

20401906 - 20493715

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112242 (version 78.38)

Entrez gene

1871

UniProt

O00716 (UniProt - Evidence at protein level)

neXtProt

NX_O00716

Antibodypedia

E2F3 antibodies
 

PROTEIN VIEW

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E2F3-001
 
E2F3-201
 
E2F3-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

E2F3-001 ENSP00000262904
ENST00000346618
O00716
Show all »
Show » Show » 465 49.2 No 0
E2F3-201 ENSP00000443418
ENST00000535432
O00716
Show all »
Show » Show » 334 37 No 0
E2F3-202 ENSP00000483249
ENST00000613242
Show » Show » 128 14.2 No 0