GAPDH

GENE INFORMATION

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Gene name

GAPDH (HGNC Symbol)

Synonyms

GAPD

Description

Glyceraldehyde-3-phosphate dehydrogenase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

6533927 - 6538374

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111640 (version 78.38)

Entrez gene

2597

UniProt

P04406 (UniProt - Evidence at protein level)

neXtProt

NX_P04406

Antibodypedia

GAPDH antibodies
 

PROTEIN VIEW

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GAPDH-001
 
GAPDH-002
 
GAPDH-003
 
GAPDH-004
 
GAPDH-008
 
GAPDH-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GAPDH-001 ENSP00000229239
ENST00000229239
P04406
Show all »
Show » Show » 335 36.1 No 0
GAPDH-002 ENSP00000380070
ENST00000396861
P04406
Show all »
Show » Show » 335 36.1 No 0
GAPDH-003 ENSP00000380068
ENST00000396859
P04406
Show all »
Show » Show » 335 36.1 No 0
GAPDH-004 ENSP00000380065
ENST00000396856
E7EUT5
Show all »
Show » Show » 260 27.9 No 0
GAPDH-008 ENSP00000380067
ENST00000396858
P04406
Show all »
Show » Show » 293 31.5 No 0
GAPDH-201 ENSP00000478864
ENST00000619601
P04406
Show all »
Show » Show » 293 31.5 No 0