CPSF6

GENERAL INFORMATION

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Gene name

CPSF6

Gene description

Cleavage and polyadenylation specific factor 6, 68kDa

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA039973
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CPSF6 (HGNC Symbol)

Synonyms

CFIM, CFIM68, HPBRII-4, HPBRII-7

Description

Cleavage and polyadenylation specific factor 6, 68kDa (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q15

Chromosome location (bp)

69239537 - 69274358

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111605 (version 78.38)

Entrez gene

11052

UniProt

Q16630 (UniProt - Evidence at protein level)

neXtProt

NX_Q16630

Antibodypedia

CPSF6 antibodies


PROTEIN BROWSER

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ENST00000266679
 
ENST00000435070
 
ENST00000456847
 
ENST00000551516
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CPSF6-001 ENSP00000391774
ENST00000435070
Q16630
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Show » Show » 551 59.2 No 0
CPSF6-003 ENSP00000391437
ENST00000456847
F8WJN3
Show all »
Show » Show » 478 52.3 No 0
CPSF6-004 ENSP00000266679
ENST00000266679
Q16630
Show all »
Show » Show » 588 63.5 No 0
CPSF6-006 ENSP00000450206
ENST00000551516
F8VNP8
Show all »
Show » 56 6.2 No 0