RASAL1

GENE INFORMATION

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Gene name

RASAL1 (HGNC Symbol)

Synonyms

RASAL

Description

RAS protein activator like 1 (GAP1 like) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]

Chromosome

12

Cytoband

q24.13

Chromosome location (bp)

113098819 - 113136239

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111344 (version 78.38)

Entrez gene

8437

UniProt

O95294 (UniProt - Evidence at protein level)

neXtProt

NX_O95294

Antibodypedia

RASAL1 antibodies
 

PROTEIN VIEW

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RASAL1-001
 
RASAL1-004
 
RASAL1-007
 
RASAL1-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RASAL1-001 ENSP00000261729
ENST00000261729
O95294
Show all »
Show » Show » 804 90 No 0
RASAL1-004 ENSP00000395920
ENST00000446861
O95294
Show all »
Show » Show » 776 86.8 No 0
RASAL1-007 ENSP00000448510
ENST00000548055
O95294
Show all »
Show » Show » 805 90.1 No 0
RASAL1-008 ENSP00000450244
ENST00000546530
O95294
Show all »
Show » Show » 806 90.3 No 0