GTF2H1 - Gene info - The Human Protein Atlas

Gene name

GTF2H1 (HGNC Symbol)

Synonyms

BTF2, P62, TFIIH

Description

General transcription factor IIH, polypeptide 1, 62kDa (HGNC Symbol)

Entrez gene summary

Chromosome

Cytoband

p15.1

Chromosome location (bp)

18322295 - 18367044

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110768 (version 78.38)

Entrez gene

2965

UniProt

P32780 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GTF2H1-001

ENSP00000265963
ENST00000265963

P32780
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P32780 [Direct mapping]
General transcription factor IIH subunit 1
B4DSG6 [Target identity:91%; Query identity:100%]
cDNA FLJ55520, highly similar to TFIIH basal transcription factor complex p62 subunit {ECO:0000313|EMBL:BAG61628.1}
E9PM51 [Target identity:43%; Query identity:100%]
General transcription factor IIH subunit 1 {ECO:0000313|Ensembl:ENSP00000433133}
F5H0Y9 [Target identity:25%; Query identity:100%]
General transcription factor IIH subunit 1 {ECO:0000313|Ensembl:ENSP00000439774}
E9PL58 [Target identity:17%; Query identity:100%]
General transcription factor IIH subunit 1 {ECO:0000313|Ensembl:ENSP00000431481}

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Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000439 [core TFIIH complex]
GO:0000718 [nucleotide-excision repair, DNA damage removal]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005675 [holo TFIIH complex]
GO:0006200 [ATP catabolic process]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006468 [protein phosphorylation]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050434 [positive regulation of viral transcription]

548

GTF2H1-002

ENSP00000393638
ENST00000453096

P32780
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Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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548

GTF2H1-003

ENSP00000435375
ENST00000534641

P32780
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P32780 [Direct mapping]
General transcription factor IIH subunit 1
E9PM51 [Target identity:54%; Query identity:100%]
General transcription factor IIH subunit 1 {ECO:0000313|Ensembl:ENSP00000433133}
F5H0Y9 [Target identity:31%; Query identity:100%]
General transcription factor IIH subunit 1 {ECO:0000313|Ensembl:ENSP00000439774}

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Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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432

48.7

GTF2H1-006

ENSP00000431481
ENST00000525831

E9PL58
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E9PL58 [Target identity:100%; Query identity:100%]
General transcription factor IIH subunit 1 {ECO:0000313|Ensembl:ENSP00000431481}

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Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000439 [core TFIIH complex]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]

10.7

GTF2H1-010

ENSP00000433133
ENST00000530496

E9PM51
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E9PM51 [Target identity:100%; Query identity:100%]
General transcription factor IIH subunit 1 {ECO:0000313|Ensembl:ENSP00000433133}
F5H0Y9 [Target identity:58%; Query identity:100%]
General transcription factor IIH subunit 1 {ECO:0000313|Ensembl:ENSP00000439774}

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Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000439 [core TFIIH complex]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]

236

26.7

GTF2H1-011

ENSP00000439774
ENST00000526630

F5H0Y9
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F5H0Y9 [Target identity:100%; Query identity:100%]
General transcription factor IIH subunit 1 {ECO:0000313|Ensembl:ENSP00000439774}

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Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000439 [core TFIIH complex]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]

138

15.8

GTF2H1-014

ENSP00000436575
ENST00000524753

E9PI26
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E9PI26 [Target identity:100%; Query identity:100%]
General transcription factor IIH subunit 1 {ECO:0000313|Ensembl:ENSP00000436575}

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Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000439 [core TFIIH complex]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]

181

20.4

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.