TCIRG1

GENE INFORMATION

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Gene name

TCIRG1 (HGNC Symbol)

Synonyms

a3, Atp6i, ATP6N1C, ATP6V0A3, OC-116, OC116, TIRC7

Description

T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (HGNC Symbol)

Entrez gene summary

Through alternate splicing, this gene encodes two proteins with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. V-ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q13.2

Chromosome location (bp)

68039016 - 68050895

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110719 (version 78.38)

Entrez gene

10312

UniProt

Q13488 (UniProt - Evidence at protein level)

neXtProt

NX_Q13488

Antibodypedia

TCIRG1 antibodies
 

PROTEIN VIEW

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TCIRG1-001
 
TCIRG1-002
 
TCIRG1-007
 
TCIRG1-011
 
TCIRG1-014
 
TCIRG1-016
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TCIRG1-001 ENSP00000265686
ENST00000265686
Q13488
Show all »
Show » Show » 830 93 No 8
TCIRG1-002 ENSP00000435023
ENST00000529657
E9PM12
Show all »
Show » Show » 218 24.4 No 0
TCIRG1-007 ENSP00000432957
ENST00000530063
Q8TCH1
Show all »
Show » Show » 61 6.8 No 0
TCIRG1-011 ENSP00000432846
ENST00000524598
E9PNA6
Show all »
Show » Show » 299 33.8 No 0
TCIRG1-014 ENSP00000431437
ENST00000529364
Show » Show » 290 32.2 No 0
TCIRG1-016 ENSP00000434407
ENST00000532635
Q13488
Show all »
Show » Show » 614 68.8 No 8