NDUFS8

GENE INFORMATION

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Gene name

NDUFS8 (HGNC Symbol)

Synonyms

CI-23k, TYKY

Description

NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome. [provided by RefSeq, Mar 2010]

Chromosome

11

Cytoband

q13.2

Chromosome location (bp)

68030617 - 68036644

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110717 (version 78.38)

Entrez gene

4728

UniProt

O00217 (UniProt - Evidence at protein level)

neXtProt

NX_O00217

Antibodypedia

NDUFS8 antibodies
 

PROTEIN VIEW

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NDUFS8-001
 
NDUFS8-004
 
NDUFS8-011
 
NDUFS8-013
 
NDUFS8-014
 
NDUFS8-015
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NDUFS8-001 ENSP00000315774
ENST00000313468
O00217
Show all »
Show » Show » 210 23.7 Yes 0
NDUFS8-004 ENSP00000432848
ENST00000528492
Q08E91
Show all »
Show » Show » 64 7.4 No 0
NDUFS8-011 ENSP00000403972
ENST00000453471
F8W9K7
Show all »
Show » Show » 124 13.9 Yes 0
NDUFS8-013 ENSP00000433521
ENST00000525419
E9PKH6
Show all »
Show » Show » 138 15.9 No 0
NDUFS8-014 ENSP00000432968
ENST00000525628
E9PN51
Show all »
Show » 110 12.4 Yes 0
NDUFS8-015 ENSP00000436287
ENST00000526339
E9PPW7
Show all »
Show » Show » 184 20.7 Yes 0