SNX15

GENE INFORMATION

? »

Gene name

SNX15

Synonyms

Description

Sorting nexin 15 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]

Chromosome

11

Cytoband

q13.1

Chromosome location (bp)

65027408 - 65040572

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110025 (version 78.38)

Entrez gene

29907

UniProt

Q9NRS6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NRS6

Antibodypedia

SNX15 antibodies
 

PROTEIN VIEW

? »
 
 
 
SNX15-001
 
SNX15-002
 
SNX15-004
 
SNX15-006
 
SNX15-007
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SNX15-001 ENSP00000366452
ENST00000377244
Q9NRS6
Show all »
Show » Show » 342 38.3 No 0
SNX15-002 ENSP00000316410
ENST00000352068
Q9NRS6
Show all »
Show » Show » 256 29.2 No 0
SNX15-004 ENSP00000437277
ENST00000534637
E9PMW6
Show all »
Show » Show » 217 24.9 No 0
SNX15-006 ENSP00000431690
ENST00000524831
E9PK26
Show all »
Show » Show » 192 22 No 0
SNX15-007 ENSP00000436023
ENST00000525648
E9PR81
Show all »
Show » 66 7 No 0