CRYAB - Gene info - The Human Protein Atlas

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CRYAB

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TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	CRYAB (HGNC Symbol)
Synonyms	CRYA2, HSPB5
Description	Crystallin, alpha B (HGNC Symbol)
Entrez gene summary	Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Chromosome	11
Cytoband	q23.1
Chromosome location (bp)	111908565 - 111923722
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109846 (version 78.38)
Entrez gene	1410
UniProt	P02511 (UniProt - Evidence at protein level)
neXtProt	NX_P02511
Antibodypedia	CRYAB antibodies

PROTEIN VIEW

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CRYAB-001		CRYAB-002		CRYAB-003		CRYAB-004		CRYAB-005		CRYAB-006		CRYAB-007		CRYAB-008		CRYAB-009		CRYAB-010		CRYAB-011		CRYAB-012		CRYAB-013		CRYAB-014		CRYAB-015		CRYAB-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
CRYAB-001	ENSP00000436051 ENST00000526180	P02511 Show all » « Hide P02511 [Direct mapping] Alpha-crystallin B chain V9HW27 [Target identity:100%; Query identity:100%] Crystallin, alpha B, isoform CRA_a {ECO:0000313\|EMBL:EAW67163.1}; Epididymis secretory protein Li 101 {ECO:0000313\|EMBL:ACI46006.1} E9PR44 [Target identity:99%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000436089} E9PJL7 [Target identity:73%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000431754} A0A024R3B9 [Target identity:61%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435046}; Crystallin, alpha B, isoform CRA_c {ECO:0000313\|EMBL:EAW67167.1} E9PNH7 [Target identity:60%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000434793} E9PS12 [Target identity:44%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000432182} E9PRS4 [Target identity:38%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435931}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005212 [structural constituent of eye lens] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006936 [muscle contraction] GO:0010941 [regulation of cell death] GO:0032387 [negative regulation of intracellular transport] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0051082 [unfolded protein binding] GO:0051260 [protein homooligomerization] GO:0070062 [extracellular vesicular exosome] GO:0071480 [cellular response to gamma radiation]	175	20.2	No	0
CRYAB-002	ENSP00000433560 ENST00000533475	P02511 Show all » « Hide P02511 [Direct mapping] Alpha-crystallin B chain V9HW27 [Target identity:100%; Query identity:100%] Crystallin, alpha B, isoform CRA_a {ECO:0000313\|EMBL:EAW67163.1}; Epididymis secretory protein Li 101 {ECO:0000313\|EMBL:ACI46006.1} E9PR44 [Target identity:99%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000436089} E9PJL7 [Target identity:73%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000431754} A0A024R3B9 [Target identity:61%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435046}; Crystallin, alpha B, isoform CRA_c {ECO:0000313\|EMBL:EAW67167.1} E9PNH7 [Target identity:60%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000434793} E9PS12 [Target identity:44%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000432182} E9PRS4 [Target identity:38%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435931}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001666 [response to hypoxia] GO:0002088 [lens development in camera-type eye] GO:0005212 [structural constituent of eye lens] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006457 [protein folding] GO:0006936 [muscle contraction] GO:0007021 [tubulin complex assembly] GO:0007517 [muscle organ development] GO:0007568 [aging] GO:0008017 [microtubule binding] GO:0008092 [cytoskeletal protein binding] GO:0009986 [cell surface] GO:0010629 [negative regulation of gene expression] GO:0010941 [regulation of cell death] GO:0015630 [microtubule cytoskeleton] GO:0030018 [Z disc] GO:0030308 [negative regulation of cell growth] GO:0031109 [microtubule polymerization or depolymerization] GO:0031674 [I band] GO:0032355 [response to estradiol] GO:0032387 [negative regulation of intracellular transport] GO:0032432 [actin filament bundle] GO:0042542 [response to hydrogen peroxide] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043010 [camera-type eye development] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043292 [contractile fiber] GO:0046872 [metal ion binding] GO:0051082 [unfolded protein binding] GO:0051260 [protein homooligomerization] GO:0051403 [stress-activated MAPK cascade] GO:0060561 [apoptotic process involved in morphogenesis] GO:0070062 [extracellular vesicular exosome] GO:0071480 [cellular response to gamma radiation] GO:2000378 [negative regulation of reactive oxygen species metabolic process]	175	20.2	No	0
CRYAB-003	ENSP00000227251 ENST00000227251	P02511 Show all » « Hide P02511 [Direct mapping] Alpha-crystallin B chain V9HW27 [Target identity:100%; Query identity:100%] Crystallin, alpha B, isoform CRA_a {ECO:0000313\|EMBL:EAW67163.1}; Epididymis secretory protein Li 101 {ECO:0000313\|EMBL:ACI46006.1} E9PR44 [Target identity:99%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000436089} E9PJL7 [Target identity:73%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000431754} A0A024R3B9 [Target identity:61%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435046}; Crystallin, alpha B, isoform CRA_c {ECO:0000313\|EMBL:EAW67167.1} E9PNH7 [Target identity:60%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000434793} E9PS12 [Target identity:44%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000432182} E9PRS4 [Target identity:38%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435931}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005212 [structural constituent of eye lens] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006936 [muscle contraction] GO:0010941 [regulation of cell death] GO:0032387 [negative regulation of intracellular transport] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0051082 [unfolded protein binding] GO:0051260 [protein homooligomerization] GO:0070062 [extracellular vesicular exosome] GO:0071480 [cellular response to gamma radiation]	175	20.2	No	0
CRYAB-004	ENSP00000434269 ENST00000533971	E9PRA8 Show all » « Hide E9PRA8 [Target identity:100%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000434269} E9PS12 [Target identity:49%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000432182} E9PRS4 [Target identity:43%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435931}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005212 [structural constituent of eye lens]	155	17.9	No	1
CRYAB-005	ENSP00000436089 ENST00000527899	E9PR44 Show all » « Hide E9PR44 [Target identity:100%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000436089} E9PJL7 [Target identity:74%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000431754} E9PNH7 [Target identity:60%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000434793} E9PS12 [Target identity:44%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000432182} E9PRS4 [Target identity:39%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435931}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005212 [structural constituent of eye lens] GO:0046872 [metal ion binding]	174	20	No	0
CRYAB-006	ENSP00000435931 ENST00000533879	E9PRS4 Show all » « Hide E9PRS4 [Target identity:98%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435931}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005212 [structural constituent of eye lens]	69	8.2	No	0
CRYAB-007	ENSP00000432182 ENST00000528628	E9PS12 Show all » « Hide E9PS12 [Target identity:100%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000432182} E9PRS4 [Target identity:88%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435931}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005212 [structural constituent of eye lens]	77	9.2	No	0
CRYAB-008	ENSP00000435411 ENST00000525823	A0A024R3B9 Show all » « Hide A0A024R3B9 [Target identity:100%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435046}; Crystallin, alpha B, isoform CRA_c {ECO:0000313\|EMBL:EAW67167.1} E9PNH7 [Target identity:98%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000434793}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005212 [structural constituent of eye lens]	108	12.3	No	0
CRYAB-009	ENSP00000435960 ENST00000528961	A0A024R3B9 Show all » « Hide A0A024R3B9 [Target identity:100%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435046}; Crystallin, alpha B, isoform CRA_c {ECO:0000313\|EMBL:EAW67167.1} E9PNH7 [Target identity:98%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000434793}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005212 [structural constituent of eye lens]	108	12.3	No	0
CRYAB-010	ENSP00000434793 ENST00000526167	E9PNH7 Show all » « Hide E9PNH7 [Target identity:100%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000434793}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005212 [structural constituent of eye lens]	106	12	No	0
CRYAB-011	ENSP00000435046 ENST00000533280	A0A024R3B9 Show all » « Hide A0A024R3B9 [Target identity:100%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435046}; Crystallin, alpha B, isoform CRA_c {ECO:0000313\|EMBL:EAW67167.1} E9PNH7 [Target identity:98%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000434793}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005212 [structural constituent of eye lens]	108	12.3	No	0
CRYAB-012	ENSP00000432454 ENST00000524660		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		106	11.7	No	0
CRYAB-013	ENSP00000437149 ENST00000527950	P02511 Show all » « Hide P02511 [Direct mapping] Alpha-crystallin B chain V9HW27 [Target identity:100%; Query identity:100%] Crystallin, alpha B, isoform CRA_a {ECO:0000313\|EMBL:EAW67163.1}; Epididymis secretory protein Li 101 {ECO:0000313\|EMBL:ACI46006.1} E9PR44 [Target identity:99%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000436089} E9PJL7 [Target identity:73%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000431754} A0A024R3B9 [Target identity:61%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435046}; Crystallin, alpha B, isoform CRA_c {ECO:0000313\|EMBL:EAW67167.1} E9PNH7 [Target identity:60%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000434793} E9PS12 [Target identity:44%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000432182} E9PRS4 [Target identity:38%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435931}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005212 [structural constituent of eye lens] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006936 [muscle contraction] GO:0010941 [regulation of cell death] GO:0032387 [negative regulation of intracellular transport] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0051082 [unfolded protein binding] GO:0051260 [protein homooligomerization] GO:0070062 [extracellular vesicular exosome] GO:0071480 [cellular response to gamma radiation]	175	20.2	No	0
CRYAB-014	ENSP00000431754 ENST00000529647	E9PJL7 Show all » « Hide E9PJL7 [Target identity:99%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000431754} E9PS12 [Target identity:59%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000432182} E9PRS4 [Target identity:52%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435931}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005212 [structural constituent of eye lens]	130	15.4	No	0
CRYAB-015	ENSP00000434247 ENST00000531198	P02511 Show all » « Hide P02511 [Direct mapping] Alpha-crystallin B chain V9HW27 [Target identity:100%; Query identity:100%] Crystallin, alpha B, isoform CRA_a {ECO:0000313\|EMBL:EAW67163.1}; Epididymis secretory protein Li 101 {ECO:0000313\|EMBL:ACI46006.1} E9PR44 [Target identity:99%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000436089} E9PJL7 [Target identity:73%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000431754} A0A024R3B9 [Target identity:61%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435046}; Crystallin, alpha B, isoform CRA_c {ECO:0000313\|EMBL:EAW67167.1} E9PNH7 [Target identity:60%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000434793} E9PS12 [Target identity:44%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000432182} E9PRS4 [Target identity:38%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435931}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005212 [structural constituent of eye lens] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006936 [muscle contraction] GO:0010941 [regulation of cell death] GO:0032387 [negative regulation of intracellular transport] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0051082 [unfolded protein binding] GO:0051260 [protein homooligomerization] GO:0070062 [extracellular vesicular exosome] GO:0071480 [cellular response to gamma radiation]	175	20.2	No	0
CRYAB-201	ENSP00000483554 ENST00000616970	P02511 Show all » « Hide P02511 [Direct mapping] Alpha-crystallin B chain V9HW27 [Target identity:100%; Query identity:100%] Crystallin, alpha B, isoform CRA_a {ECO:0000313\|EMBL:EAW67163.1}; Epididymis secretory protein Li 101 {ECO:0000313\|EMBL:ACI46006.1} E9PR44 [Target identity:99%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000436089} E9PJL7 [Target identity:73%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000431754} A0A024R3B9 [Target identity:61%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435046}; Crystallin, alpha B, isoform CRA_c {ECO:0000313\|EMBL:EAW67167.1} E9PNH7 [Target identity:60%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000434793} E9PS12 [Target identity:44%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000432182} E9PRS4 [Target identity:38%; Query identity:100%] Alpha-crystallin B chain {ECO:0000313\|Ensembl:ENSP00000435931}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005212 [structural constituent of eye lens] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006936 [muscle contraction] GO:0010941 [regulation of cell death] GO:0032387 [negative regulation of intracellular transport] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0051082 [unfolded protein binding] GO:0051260 [protein homooligomerization] GO:0070062 [extracellular vesicular exosome] GO:0071480 [cellular response to gamma radiation]	175	20.2	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.