CLCN3

GENE INFORMATION

? »

Gene name

CLCN3 (HGNC Symbol)

Synonyms

ClC-3, CLC3

Description

Chloride channel, voltage-sensitive 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Chromosome

4

Cytoband

q33

Chromosome location (bp)

169612633 - 169723673

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000109572 (version 78.38)

Entrez gene

1182

UniProt

P51790 (UniProt - Evidence at protein level)

neXtProt

NX_P51790

Antibodypedia

CLCN3 antibodies
 

PROTEIN VIEW

? »
 
 
 
CLCN3-001
 
CLCN3-002
 
CLCN3-004
 
CLCN3-005
 
CLCN3-006
 
CLCN3-007
 
CLCN3-009
 
CLCN3-201
 
CLCN3-202
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLCN3-001 ENSP00000424603
ENST00000513761
P51790
Show all »
Show » Show » 818 91 No >9
CLCN3-002 ENSP00000261514
ENST00000347613
P51790
Show all »
Show » Show » 866 96.7 No >9
CLCN3-004 ENSP00000353857
ENST00000360642
P51790
Show all »
Show » Show » 791 88.5 No >9
CLCN3-005 ENSP00000425323
ENST00000507875
E9PE15
Show all »
Show » Show » 725 80.5 No >9
CLCN3-006 ENSP00000425160
ENST00000511092
D6RDZ6
Show all »
Show » Show » 173 19.4 No 1
CLCN3-007 ENSP00000425823
ENST00000512813
D6RIX3
Show all »
Show » Show » 139 15.7 No 0
CLCN3-009 ENSP00000422678
ENST00000515420
Show » Show » 245 26.7 No 6
CLCN3-201 ENSP00000424540
ENST00000504131
Show » Show » 801 88.8 No >9
CLCN3-202 ENSP00000478336
ENST00000613795
E9PE15
Show all »
Show » Show » 791 87.9 No >9