UBE2D3 - Gene info - The Human Protein Atlas

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UBE2D3

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	UBE2D3 (HGNC Symbol)
Synonyms	UbcH5C
Description	Ubiquitin-conjugating enzyme E2D 3 (HGNC Symbol)
Entrez gene summary	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q24
Chromosome location (bp)	102794383 - 102868896
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109332 (version 78.38)
Entrez gene	7323
UniProt	P61077 (UniProt - Evidence at protein level)
neXtProt	NX_P61077
Antibodypedia	UBE2D3 antibodies

PROTEIN VIEW

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UBE2D3-001		UBE2D3-002		UBE2D3-003		UBE2D3-004		UBE2D3-005		UBE2D3-006		UBE2D3-009		UBE2D3-010		UBE2D3-011		UBE2D3-012		UBE2D3-013		UBE2D3-014		UBE2D3-015		UBE2D3-016		UBE2D3-017		UBE2D3-018		UBE2D3-019		UBE2D3-201		UBE2D3-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
UBE2D3-001	ENSP00000396901 ENST00000453744	P61077 Show all » « Hide P61077 [Direct mapping] Ubiquitin-conjugating enzyme E2 D3 A0A024RDH2 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), isoform CRA_a {ECO:0000313\|EMBL:EAX06144.1} D6RAH7 [Target identity:80%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421904} D6RFM0 [Target identity:66%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D2 {ECO:0000313\|Ensembl:ENSP00000426523} D6RA11 [Target identity:65%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000423487} D6RIZ3 [Target identity:53%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000425762} D6RAW0 [Target identity:48%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000424710} D6RGD0 [Target identity:33%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421310}	Show » « Hide Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000209 [protein polyubiquitination] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006464 [cellular protein modification process] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006513 [protein monoubiquitination] GO:0006915 [apoptotic process] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008152 [metabolic process] GO:0010467 [gene expression] GO:0016567 [protein ubiquitination] GO:0016881 [acid-amino acid ligase activity] GO:0030509 [BMP signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045087 [innate immune response] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070062 [extracellular vesicular exosome] GO:0070936 [protein K48-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] GO:0071456 [cellular response to hypoxia]	147	16.7	No	0
UBE2D3-002	ENSP00000345285 ENST00000343106	P61077 Show all » « Hide P61077 [Direct mapping] Ubiquitin-conjugating enzyme E2 D3 D6RFM0 [Target identity:66%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D2 {ECO:0000313\|Ensembl:ENSP00000426523} D6RA11 [Target identity:64%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000423487} D6RIZ3 [Target identity:52%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000425762} D6RAW0 [Target identity:48%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000424710} D6RGD0 [Target identity:33%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421310}	Show » « Hide Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000209 [protein polyubiquitination] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006464 [cellular protein modification process] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006513 [protein monoubiquitination] GO:0006915 [apoptotic process] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008152 [metabolic process] GO:0010467 [gene expression] GO:0016567 [protein ubiquitination] GO:0016881 [acid-amino acid ligase activity] GO:0030509 [BMP signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045087 [innate immune response] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070062 [extracellular vesicular exosome] GO:0070936 [protein K48-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] GO:0071456 [cellular response to hypoxia]	148	16.8	No	0
UBE2D3-003	ENSP00000349722 ENST00000357194	P61077 Show all » « Hide P61077 [Direct mapping] Ubiquitin-conjugating enzyme E2 D3 D6RAH7 [Target identity:79%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421904} D6RFM0 [Target identity:65%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D2 {ECO:0000313\|Ensembl:ENSP00000426523} D6RAW0 [Target identity:48%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000424710}	Show » « Hide Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000209 [protein polyubiquitination] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006464 [cellular protein modification process] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006513 [protein monoubiquitination] GO:0006915 [apoptotic process] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008152 [metabolic process] GO:0010467 [gene expression] GO:0016567 [protein ubiquitination] GO:0016881 [acid-amino acid ligase activity] GO:0030509 [BMP signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045087 [innate immune response] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070062 [extracellular vesicular exosome] GO:0070936 [protein K48-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] GO:0071456 [cellular response to hypoxia]	149	16.9	No	0
UBE2D3-004	ENSP00000378280 ENST00000394801	P61077 Show all » « Hide P61077 [Direct mapping] Ubiquitin-conjugating enzyme E2 D3 A0A024RDH2 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), isoform CRA_a {ECO:0000313\|EMBL:EAX06144.1} D6RAH7 [Target identity:80%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421904} D6RFM0 [Target identity:66%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D2 {ECO:0000313\|Ensembl:ENSP00000426523} D6RA11 [Target identity:65%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000423487} D6RIZ3 [Target identity:53%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000425762} D6RAW0 [Target identity:48%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000424710} D6RGD0 [Target identity:33%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421310}	Show » « Hide Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000209 [protein polyubiquitination] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006464 [cellular protein modification process] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006513 [protein monoubiquitination] GO:0006915 [apoptotic process] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008152 [metabolic process] GO:0010467 [gene expression] GO:0016567 [protein ubiquitination] GO:0016881 [acid-amino acid ligase activity] GO:0030509 [BMP signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045087 [innate immune response] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070062 [extracellular vesicular exosome] GO:0070936 [protein K48-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] GO:0071456 [cellular response to hypoxia]	147	16.7	No	0
UBE2D3-005	ENSP00000378282 ENST00000394803	P61077 Show all » « Hide P61077 [Direct mapping] Ubiquitin-conjugating enzyme E2 D3 A0A024RDH2 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), isoform CRA_a {ECO:0000313\|EMBL:EAX06144.1} D6RAH7 [Target identity:80%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421904} D6RFM0 [Target identity:66%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D2 {ECO:0000313\|Ensembl:ENSP00000426523} D6RA11 [Target identity:65%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000423487} D6RIZ3 [Target identity:53%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000425762} D6RAW0 [Target identity:48%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000424710} D6RGD0 [Target identity:33%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421310}	Show » « Hide Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000209 [protein polyubiquitination] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006464 [cellular protein modification process] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006513 [protein monoubiquitination] GO:0006915 [apoptotic process] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008152 [metabolic process] GO:0010467 [gene expression] GO:0016567 [protein ubiquitination] GO:0016881 [acid-amino acid ligase activity] GO:0030509 [BMP signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045087 [innate immune response] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070062 [extracellular vesicular exosome] GO:0070936 [protein K48-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] GO:0071456 [cellular response to hypoxia]	147	16.7	No	0
UBE2D3-006	ENSP00000337208 ENST00000338145	P61077 Show all » « Hide P61077 [Direct mapping] Ubiquitin-conjugating enzyme E2 D3 A0A024RDH2 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), isoform CRA_a {ECO:0000313\|EMBL:EAX06144.1} D6RAH7 [Target identity:80%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421904} D6RFM0 [Target identity:66%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D2 {ECO:0000313\|Ensembl:ENSP00000426523} D6RA11 [Target identity:65%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000423487} D6RIZ3 [Target identity:53%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000425762} D6RAW0 [Target identity:48%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000424710} D6RGD0 [Target identity:33%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421310}	Show » « Hide Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000209 [protein polyubiquitination] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006464 [cellular protein modification process] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006513 [protein monoubiquitination] GO:0006915 [apoptotic process] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008152 [metabolic process] GO:0010467 [gene expression] GO:0016567 [protein ubiquitination] GO:0016881 [acid-amino acid ligase activity] GO:0030509 [BMP signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045087 [innate immune response] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070062 [extracellular vesicular exosome] GO:0070936 [protein K48-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] GO:0071456 [cellular response to hypoxia]	147	16.7	No	0
UBE2D3-009	ENSP00000423487 ENST00000508238	D6RA11 Show all » « Hide D6RA11 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000423487} D6RIZ3 [Target identity:81%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000425762} D6RGD0 [Target identity:51%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421310}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0008152 [metabolic process] GO:0016881 [acid-amino acid ligase activity]	96	10.7	No	0
UBE2D3-010	ENSP00000421310 ENST00000508249	D6RGD0 Show all » « Hide D6RGD0 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421310}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0008152 [metabolic process] GO:0016881 [acid-amino acid ligase activity]	49	5.3	No	0
UBE2D3-011	ENSP00000425762 ENST00000502690	D6RIZ3 Show all » « Hide D6RIZ3 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000425762} D6RGD0 [Target identity:62%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421310}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0008152 [metabolic process] GO:0016881 [acid-amino acid ligase activity]	78	8.8	No	0
UBE2D3-012	ENSP00000344069 ENST00000349311	P61077 Show all » « Hide P61077 [Direct mapping] Ubiquitin-conjugating enzyme E2 D3 A0A024RDH2 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), isoform CRA_a {ECO:0000313\|EMBL:EAX06144.1} D6RAH7 [Target identity:80%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421904} D6RFM0 [Target identity:66%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D2 {ECO:0000313\|Ensembl:ENSP00000426523} D6RA11 [Target identity:65%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000423487} D6RIZ3 [Target identity:53%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000425762} D6RAW0 [Target identity:48%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000424710} D6RGD0 [Target identity:33%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421310}	Show » « Hide Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000209 [protein polyubiquitination] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006464 [cellular protein modification process] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006513 [protein monoubiquitination] GO:0006915 [apoptotic process] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008152 [metabolic process] GO:0010467 [gene expression] GO:0016567 [protein ubiquitination] GO:0016881 [acid-amino acid ligase activity] GO:0030509 [BMP signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045087 [innate immune response] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070062 [extracellular vesicular exosome] GO:0070936 [protein K48-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] GO:0071456 [cellular response to hypoxia]	147	16.7	No	0
UBE2D3-013	ENSP00000318494 ENST00000321805	P61077 Show all » « Hide P61077 [Direct mapping] Ubiquitin-conjugating enzyme E2 D3 A0A024RDH2 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), isoform CRA_a {ECO:0000313\|EMBL:EAX06144.1} D6RAH7 [Target identity:80%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421904} D6RFM0 [Target identity:66%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D2 {ECO:0000313\|Ensembl:ENSP00000426523} D6RA11 [Target identity:65%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000423487} D6RIZ3 [Target identity:53%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000425762} D6RAW0 [Target identity:48%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000424710} D6RGD0 [Target identity:33%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421310}	Show » « Hide Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000209 [protein polyubiquitination] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006464 [cellular protein modification process] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006513 [protein monoubiquitination] GO:0006915 [apoptotic process] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008152 [metabolic process] GO:0010467 [gene expression] GO:0016567 [protein ubiquitination] GO:0016881 [acid-amino acid ligase activity] GO:0030509 [BMP signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045087 [innate immune response] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070062 [extracellular vesicular exosome] GO:0070936 [protein K48-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] GO:0071456 [cellular response to hypoxia]	147	16.7	No	0
UBE2D3-014	ENSP00000337262 ENST00000350435	H9KV45 Show all » « Hide H9KV45 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000337262} D6RAH7 [Target identity:83%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421904} D6RFM0 [Target identity:69%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D2 {ECO:0000313\|Ensembl:ENSP00000426523} D6RAW0 [Target identity:51%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000424710}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0008152 [metabolic process] GO:0016881 [acid-amino acid ligase activity]	141	15.9	No	0
UBE2D3-015	ENSP00000426586 ENST00000505207	D6RAH7 Show all » « Hide D6RAH7 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421904} D6RFM0 [Target identity:83%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D2 {ECO:0000313\|Ensembl:ENSP00000426523} D6RAW0 [Target identity:61%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000424710}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0008152 [metabolic process] GO:0016881 [acid-amino acid ligase activity]	118	13.6	No	0
UBE2D3-016	ENSP00000424359 ENST00000507845	D6RAH7 Show all » « Hide D6RAH7 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421904} D6RFM0 [Target identity:83%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D2 {ECO:0000313\|Ensembl:ENSP00000426523} D6RAW0 [Target identity:61%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000424710}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0008152 [metabolic process] GO:0016881 [acid-amino acid ligase activity]	118	13.6	No	0
UBE2D3-017	ENSP00000421904 ENST00000502404	D6RAH7 Show all » « Hide D6RAH7 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421904} D6RFM0 [Target identity:83%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D2 {ECO:0000313\|Ensembl:ENSP00000426523} D6RAW0 [Target identity:61%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000424710}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0008152 [metabolic process] GO:0016881 [acid-amino acid ligase activity]	118	13.6	No	0
UBE2D3-018	ENSP00000424710 ENST00000508476	D6RAW0 Show all » « Hide D6RAW0 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000424710}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0008152 [metabolic process] GO:0016881 [acid-amino acid ligase activity]	72	8.2	No	0
UBE2D3-019	ENSP00000426620 ENST00000504211	D6RAH7 Show all » « Hide D6RAH7 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421904} D6RFM0 [Target identity:83%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D2 {ECO:0000313\|Ensembl:ENSP00000426523} D6RAW0 [Target identity:61%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000424710}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0008152 [metabolic process] GO:0016881 [acid-amino acid ligase activity]	118	13.6	No	0
UBE2D3-201	ENSP00000378283 ENST00000394804	P61077 Show all » « Hide P61077 [Direct mapping] Ubiquitin-conjugating enzyme E2 D3 A0A024RDH2 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), isoform CRA_a {ECO:0000313\|EMBL:EAX06144.1} D6RAH7 [Target identity:80%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421904} D6RFM0 [Target identity:66%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D2 {ECO:0000313\|Ensembl:ENSP00000426523} D6RA11 [Target identity:65%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000423487} D6RIZ3 [Target identity:53%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000425762} D6RAW0 [Target identity:48%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000424710} D6RGD0 [Target identity:33%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421310}	Show » « Hide Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000209 [protein polyubiquitination] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006464 [cellular protein modification process] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006513 [protein monoubiquitination] GO:0006915 [apoptotic process] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008152 [metabolic process] GO:0010467 [gene expression] GO:0016567 [protein ubiquitination] GO:0016881 [acid-amino acid ligase activity] GO:0030509 [BMP signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045087 [innate immune response] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070062 [extracellular vesicular exosome] GO:0070936 [protein K48-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] GO:0071456 [cellular response to hypoxia]	147	16.7	No	0
UBE2D3-202	ENSP00000481600 ENST00000618836	D6RAH7 Show all » « Hide D6RAH7 [Target identity:79%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000421904} D6RFM0 [Target identity:66%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D2 {ECO:0000313\|Ensembl:ENSP00000426523} D6RAW0 [Target identity:48%; Query identity:100%] Ubiquitin-conjugating enzyme E2 D3 {ECO:0000313\|Ensembl:ENSP00000424710}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0008152 [metabolic process] GO:0016881 [acid-amino acid ligase activity]	148	16.8	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.