AREG

GENE INFORMATION

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Gene name

AREG (HGNC Symbol)

Synonyms

AREGB, SDGF

Description

Amphiregulin (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]

Chromosome

4

Cytoband

q13.3

Chromosome location (bp)

74445134 - 74455009

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000109321 (version 78.38)

Entrez gene

374

UniProt

P15514 (UniProt - Evidence at protein level)

neXtProt

NX_P15514

Antibodypedia

AREG antibodies
 

PROTEIN VIEW

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AREG-001
 
AREG-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AREG-001 ENSP00000379097
ENST00000395748
P15514
Show all »
Show » Show » 252 27.9 Yes 1
AREG-002 ENSP00000421414
ENST00000502307
D6RFX5
Show all »
Show » Show » 274 30.3 Yes 1