NFKB1

GENERAL INFORMATION

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Gene name

NFKB1

Gene description

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

Protein class

Cancer-related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear and cytoplasmic expression, most abundant in lymphoid tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA027305 , CAB004031
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

NFKB1 (HGNC Symbol)

Synonyms

KBF1, NF-kappaB, NF-kB1, NFkappaB, NFKB-p50, p105, p50

Description

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

4

Cytoband

q24

Chromosome location (bp)

102501329 - 102617302

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000109320 (version 78.38)

Entrez gene

4790

UniProt

P19838 (UniProt - Evidence at protein level)

neXtProt

NX_P19838

Antibodypedia

NFKB1 antibodies


PROTEIN BROWSER

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ENST00000226574
 
ENST00000394820
 
ENST00000505458
 
ENST00000507079
 
ENST00000508584
 
ENST00000509165
 
ENST00000511926
 
ENST00000600343
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NFKB1-001 ENSP00000226574
ENST00000226574
P19838
Show all »
Show » Show » 969 105.4 No 0
NFKB1-002 ENSP00000378297
ENST00000394820
P19838
Show all »
Show » Show » 968 105.4 No 0
NFKB1-003 ENSP00000424790
ENST00000505458
P19838
Show all »
Show » Show » 968 105.4 No 0
NFKB1-004 ENSP00000426147
ENST00000507079
D6RH30
Show all »
Show » Show » 198 21.9 No 0
NFKB1-005 ENSP00000420904
ENST00000511926
D6RDI9
Show all »
Show » Show » 74 8.7 No 0
NFKB1-007 ENSP00000423877
ENST00000509165
D6RC45
Show all »
Show » Show » 145 15.9 No 0
NFKB1-011 ENSP00000424815
ENST00000508584
D6RF93
Show all »
Show » Show » 196 21.4 No 0
NFKB1-013 ENSP00000469340
ENST00000600343
P19838
Show all »
Show » Show » 788 85.5 No 0