PPY

GENE INFORMATION

? »

Gene name

PPY (HGNC Symbol)

Synonyms

PNP

Description

Pancreatic polypeptide (HGNC Symbol)

Entrez gene summary

This gene belongs to the NPY family and it encodes a protein that is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q21.31

Chromosome location (bp)

43940804 - 43942468

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000108849 (version 78.38)

Entrez gene

5539

UniProt

P01298 (UniProt - Evidence at protein level)

neXtProt

NX_P01298

Antibodypedia

PPY antibodies
 

PROTEIN VIEW

? »
 
 
 
PPY-001
 
PPY-002
 
PPY-004
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PPY-001 ENSP00000225992
ENST00000225992
P01298
Show all »
Show » Show » 95 10.4 Yes 0
PPY-002 ENSP00000466009
ENST00000591228
P01298
Show all »
Show » Show » 95 10.4 Yes 0
PPY-004 ENSP00000465711
ENST00000587006
K7EKP2
Show all »
Show » Show » 105 11.5 Yes 0