PFN1

GENE INFORMATION

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Gene name

PFN1

Synonyms

Description

Profilin 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]

Chromosome

17

Cytoband

p13.2

Chromosome location (bp)

4945652 - 4949061

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000108518 (version 78.38)

Entrez gene

5216

UniProt

P07737 (UniProt - Evidence at protein level)

neXtProt

NX_P07737

Antibodypedia

PFN1 antibodies
 

PROTEIN VIEW

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PFN1-001
 
PFN1-002
 
PFN1-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PFN1-001 ENSP00000225655
ENST00000225655
P07737
Show all »
Show » Show » 140 15.1 No 0
PFN1-002 ENSP00000465019
ENST00000574872
K7EJ44
Show all »
Show » Show » 104 11.4 No 0
PFN1-003 ENSP00000460363
ENST00000572383
I3L3D5
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Show » Show » 165 17.5 Yes 0