CYP2C18

GENE INFORMATION

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Gene name

CYP2C18 (HGNC Symbol)

Synonyms

CPCI, CYP2C, CYP2C17, P450IIC17

Description

Cytochrome P450, family 2, subfamily C, polypeptide 18 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q23.33

Chromosome location (bp)

94683621 - 94736190

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000108242 (version 78.38)

Entrez gene

1562

UniProt

P33260 (UniProt - Evidence at protein level)

neXtProt

NX_P33260

Antibodypedia

CYP2C18 antibodies
 

PROTEIN VIEW

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CYP2C18-001
 
CYP2C18-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP2C18-001 ENSP00000285979
ENST00000285979
P33260
Show all »
Show » Show » 490 55.7 Yes 0
CYP2C18-002 ENSP00000341293
ENST00000339022
P33260
Show all »
Show » Show » 431 48.8 Yes 0