TFAM

GENE INFORMATION

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Gene name

TFAM (HGNC Symbol)

Synonyms

TCF6, TCF6L2

Description

Transcription factor A, mitochondrial (HGNC Symbol)

Entrez gene summary

This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Chromosome

10

Cytoband

q21.1

Chromosome location (bp)

58385022 - 58399221

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000108064 (version 78.38)

Entrez gene

7019

UniProt

Q00059 (UniProt - Evidence at protein level)

neXtProt

NX_Q00059

Antibodypedia

TFAM antibodies
 

PROTEIN VIEW

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TFAM-001
 
TFAM-002
 
TFAM-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TFAM-001 ENSP00000378776
ENST00000395377
Show » 219 25.6 No 0
TFAM-002 ENSP00000420588
ENST00000487519
Q00059
Show all »
Show » Show » 246 29.1 Yes 0
TFAM-004 ENSP00000363002
ENST00000373895
Q00059
Show all »
Show » Show » 214 25.5 Yes 0