GTPBP4

GENERAL INFORMATION

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Gene name

GTPBP4

Gene description

GTP binding protein 4

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues showed moderate to strong cytoplasmic and nucleolar staining. Lung, liver, islet cells, cells in glomeruli and glial cells were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA039618
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

GTPBP4 (HGNC Symbol)

Synonyms

CRFG, FLJ10686, FLJ10690, NGB, NOG1

Description

GTP binding protein 4 (HGNC Symbol)

Entrez gene summary

GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

p15.3

Chromosome location (bp)

988019 - 1019936

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000107937 (version 78.38)

Entrez gene

23560

UniProt

Q9BZE4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BZE4

Antibodypedia

GTPBP4 antibodies


PROTEIN BROWSER

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ENST00000360059
 
ENST00000360803
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GTPBP4-001 ENSP00000354040
ENST00000360803
Q9BZE4
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Show » Show » 634 74 No 0
GTPBP4-006 ENSP00000353168
ENST00000360059
Q5T3R7
Show all »
Show » 140 16.5 No 0