DNTT

GENE INFORMATION

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Gene name

DNTT (HGNC Symbol)

Synonyms

TDT

Description

DNA nucleotidylexotransferase (HGNC Symbol)

Entrez gene summary

This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q24.1

Chromosome location (bp)

96304396 - 96338564

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000107447 (version 78.38)

Entrez gene

1791

UniProt

P04053 (UniProt - Evidence at protein level)

neXtProt

NX_P04053

Antibodypedia

DNTT antibodies
 

PROTEIN VIEW

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DNTT-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DNTT-001 ENSP00000360216
ENST00000371174
P04053
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