POLD2

GENE INFORMATION

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Gene name

POLD2

Synonyms

Description

Polymerase (DNA directed), delta 2, accessory subunit (HGNC Symbol)

Entrez gene summary

This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]

Chromosome

7

Cytoband

p13

Chromosome location (bp)

44114681 - 44124358

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106628 (version 78.38)

Entrez gene

5425

UniProt

P49005 (UniProt - Evidence at protein level)

neXtProt

NX_P49005

Antibodypedia

POLD2 antibodies
 

PROTEIN VIEW

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POLD2-001
 
POLD2-002
 
POLD2-003
 
POLD2-004
 
POLD2-005
 
POLD2-007
 
POLD2-010
 
POLD2-017
 
POLD2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

POLD2-001 ENSP00000386105
ENST00000406581
P49005
Show all »
Show » Show » 469 51.3 No 0
POLD2-002 ENSP00000395231
ENST00000452185
P49005
Show all »
Show » Show » 469 51.3 No 0
POLD2-003 ENSP00000223361
ENST00000223361
F8W8R3
Show all »
Show » Show » 455 49.6 No 0
POLD2-004 ENSP00000389816
ENST00000433715
C9JLE1
Show all »
Show » Show » 220 24.3 No 0
POLD2-005 ENSP00000406702
ENST00000418438
C9IZD2
Show all »
Show » 148 16.9 No 0
POLD2-007 ENSP00000397461
ENST00000456038
C9J8Z7
Show all »
Show » 155 17.6 No 0
POLD2-010 ENSP00000416203
ENST00000436844
C9JHC7
Show all »
Show » Show » 257 27.9 No 0
POLD2-017 ENSP00000399447
ENST00000436400
H7C1B3
Show all »
Show » Show » 83 9.2 No 0
POLD2-201 ENSP00000480186
ENST00000610533
C9JLE1
Show all »
Show » Show » 504 54.7 No 0