IMPDH1

GENE INFORMATION

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Gene name

IMPDH1 (HGNC Symbol)

Synonyms

LCA11, RP10, sWSS2608

Description

IMP (inosine 5'-monophosphate) dehydrogenase 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Chromosome

7

Cytoband

q32.1

Chromosome location (bp)

128392277 - 128410252

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106348 (version 78.38)

Entrez gene

3614

UniProt

P20839 (UniProt - Evidence at protein level)

neXtProt

NX_P20839

Antibodypedia

IMPDH1 antibodies
 

PROTEIN VIEW

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IMPDH1-001
 
IMPDH1-002
 
IMPDH1-003
 
IMPDH1-005
 
IMPDH1-007
 
IMPDH1-008
 
IMPDH1-009
 
IMPDH1-012
 
IMPDH1-016
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IMPDH1-001 ENSP00000346219
ENST00000354269
P20839
Show all »
Show » Show » 589 63.3 No 0
IMPDH1-002 ENSP00000265385
ENST00000348127
P20839
Show all »
Show » Show » 563 60.4 No 0
IMPDH1-003 ENSP00000399400
ENST00000419067
P20839
Show all »
Show » Show » 566 60.9 No 0
IMPDH1-005 ENSP00000345096
ENST00000338791
P20839
Show all »
Show » Show » 599 64.3 No 0
IMPDH1-007 ENSP00000419609
ENST00000497868
C9K0R9
Show all »
Show » Show » 289 31.2 No 0
IMPDH1-008 ENSP00000420803
ENST00000496200
P20839
Show all »
Show » Show » 489 52.6 No 0
IMPDH1-009 ENSP00000420185
ENST00000480861
P20839
Show all »
Show » Show » 509 54.8 No 0
IMPDH1-012 ENSP00000418592
ENST00000489263
C9J029
Show all »
Show » Show » 184 19.5 No 0
IMPDH1-016 ENSP00000417296
ENST00000470772
C9J381
Show all »
Show » Show » 513 55.3 No 0