SPAM1

GENE INFORMATION

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Gene name

SPAM1 (HGNC Symbol)

Synonyms

HYAL5, PH-20, SPAG15

Description

Sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (HGNC Symbol)

Entrez gene summary

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Chromosome

7

Cytoband

q31.32

Chromosome location (bp)

123925237 - 123971414

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106304 (version 78.38)

Entrez gene

6677

UniProt

P38567 (UniProt - Evidence at protein level)

neXtProt

NX_P38567

Antibodypedia

SPAM1 antibodies
 

PROTEIN VIEW

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SPAM1-001
 
SPAM1-002
 
SPAM1-003
 
SPAM1-005
 
SPAM1-201
 
SPAM1-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPAM1-001 ENSP00000402123
ENST00000439500
P38567
Show all »
Show » Show » 509 57.8 No 2
SPAM1-002 ENSP00000345849
ENST00000340011
P38567
Show all »
Show » Show » 511 58.4 No 0
SPAM1-003 ENSP00000391491
ENST00000413927
C9J2X5
Show all »
Show » Show » 80 9.1 No 0
SPAM1-005 ENSP00000417934
ENST00000460182
P38567
Show all »
Show » Show » 509 57.8 No 2
SPAM1-201 ENSP00000223028
ENST00000223028
P38567
Show all »
Show » Show » 509 57.8 No 2
SPAM1-202 ENSP00000386028
ENST00000402183
P38567
Show all »
Show » Show » 511 58.4 No 0