HPN - Gene info - The Human Protein Atlas

Gene name

HPN (HGNC Symbol)

Synonyms

TMPRSS1

Description

Hepsin (HGNC Symbol)

Entrez gene summary

This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Chromosome

Cytoband

q13.11

Chromosome location (bp)

35040506 - 35066571

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105707 (version 78.38)

Entrez gene

3249

UniProt

P05981 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HPN-001

ENSP00000376060
ENST00000392226

P05981
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P05981 [Direct mapping]
Serine protease hepsin Serine protease hepsin non-catalytic chain Serine protease hepsin catalytic chain
B2ZDQ2 [Target identity:96%; Query identity:100%]
Truncated hepsin serine protease {ECO:0000313|EMBL:ACD02430.1}
M0R244 [Target identity:19%; Query identity:100%]
Serine protease hepsin {ECO:0000313|Ensembl:ENSP00000472310}

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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0003824 [catalytic activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008236 [serine-type peptidase activity]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010756 [positive regulation of plasminogen activation]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030307 [positive regulation of cell growth]
GO:0031965 [nuclear membrane]
GO:0034769 [basement membrane disassembly]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043923 [positive regulation by host of viral transcription]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound]
GO:0070008 [serine-type exopeptidase activity]
GO:0070062 [extracellular vesicular exosome]
GO:0071805 [potassium ion transmembrane transport]
GO:0090103 [cochlea morphogenesis]
GO:0097066 [response to thyroid hormone]
GO:0097195 [pilomotor reflex]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2000611 [positive regulation of thyroid hormone generation]

417

HPN-002

ENSP00000262626
ENST00000262626

P05981
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GO:0003824 [catalytic activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006508 [proteolysis]
GO:0007605 [sensory perception of sound]
GO:0008233 [peptidase activity]
GO:0008236 [serine-type peptidase activity]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010693 [negative regulation of alkaline phosphatase activity]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010756 [positive regulation of plasminogen activation]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030307 [positive regulation of cell growth]
GO:0031965 [nuclear membrane]
GO:0034769 [basement membrane disassembly]
GO:0042632 [cholesterol homeostasis]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043923 [positive regulation by host of viral transcription]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound]
GO:0070008 [serine-type exopeptidase activity]
GO:0070062 [extracellular vesicular exosome]
GO:0071805 [potassium ion transmembrane transport]
GO:0090103 [cochlea morphogenesis]
GO:0097066 [response to thyroid hormone]
GO:0097195 [pilomotor reflex]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2000611 [positive regulation of thyroid hormone generation]

417

HPN-005

ENSP00000470327
ENST00000597419

M0QZ63
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M0QZ63 [Target identity:100%; Query identity:100%]
Serine protease hepsin {ECO:0000313|Ensembl:ENSP00000470327}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0003824 [catalytic activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0016020 [membrane]
GO:0070008 [serine-type exopeptidase activity]

259

28.1

HPN-007

ENSP00000472310
ENST00000600390

M0R244
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M0R244 [Target identity:100%; Query identity:100%]
Serine protease hepsin {ECO:0000313|Ensembl:ENSP00000472310}

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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0070008 [serine-type exopeptidase activity]

8.5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.