BBC3

GENE INFORMATION

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Gene name

BBC3 (HGNC Symbol)

Synonyms

JFY1, PUMA

Description

BCL2 binding component 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Chromosome

19

Cytoband

q13.32

Chromosome location (bp)

47220822 - 47232766

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105327 (version 78.38)

Entrez gene

27113

UniProt

Q96PG8 (UniProt - Evidence at transcript level), Q9BXH1 (UniProt - Evidence at protein level)

neXtProt

NX_Q96PG8, NX_Q9BXH1

Antibodypedia

BBC3 antibodies
 

PROTEIN VIEW

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BBC3-001
 
BBC3-002
 
BBC3-003
 
BBC3-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BBC3-001 ENSP00000404503
ENST00000449228
Q96PG8
Show all »
Show » Show » 261 26.5 No 0
BBC3-002 ENSP00000341155
ENST00000341983
Show » 131 14.5 No 0
BBC3-003 ENSP00000395862
ENST00000439096
Q9BXH1
Show all »
Show » Show » 193 20.5 No 0
BBC3-005 ENSP00000300880
ENST00000300880
Show » 101 10.3 No 0