GPI

GENE INFORMATION

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Gene name

GPI (HGNC Symbol)

Synonyms

AMF, NLK

Description

Glucose-6-phosphate isomerase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Chromosome

19

Cytoband

q13.11

Chromosome location (bp)

34359480 - 34402156

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105220 (version 78.38)

Entrez gene

2821

UniProt

P06744 (UniProt - Evidence at protein level)

neXtProt

NX_P06744

Antibodypedia

GPI antibodies
 

PROTEIN VIEW

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 « 
 
GPI-001
 
GPI-002
 
GPI-003
 
GPI-004
 
GPI-005
 
GPI-006
 
GPI-008
 
GPI-009
 
GPI-012
 
GPI-018
 
GPI-019
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GPI-001 ENSP00000405573
ENST00000415930
P06744
Show all »
Show » Show » 569 64.3 No 1
GPI-002 ENSP00000465858
ENST00000588991
K7EP41
Show all »
Show » Show » 573 64.8 No 2
GPI-003 ENSP00000464797
ENST00000587521
K7EIL4
Show all »
Show » Show » 110 12.7 No 0
GPI-004 ENSP00000466191
ENST00000592277
K7ELR7
Show all »
Show » Show » 146 16.8 No 0
GPI-005 ENSP00000468298
ENST00000587384
K7ERK8
Show all »
Show » Show » 133 15.4 No 0
GPI-006 ENSP00000348877
ENST00000356487
P06744
Show all »
Show » Show » 558 63.1 No 2
GPI-008 ENSP00000467221
ENST00000590375
K7EP41
Show all »
Show » Show » 159 18.3 No 0
GPI-009 ENSP00000468201
ENST00000589399
K7ERC6
Show all »
Show » Show » 162 18.7 No 0
GPI-012 ENSP00000467670
ENST00000586425
K7EQ48
Show all »
Show » Show » 474 53.4 No 1
GPI-018 ENSP00000466851
ENST00000591204
K7ENA0
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Show » Show » 163 18.6 No 0
GPI-019 ENSP00000467590
ENST00000589640
K7EPY4
Show all »
Show » Show » 167 19.2 No 0