WISP1

GENE INFORMATION

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Gene name

WISP1 (HGNC Symbol)

Synonyms

CCN4

Description

WNT1 inducible signaling pathway protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]

Chromosome

8

Cytoband

q24.22

Chromosome location (bp)

133191039 - 133230344

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000104415 (version 78.38)

Entrez gene

8840

UniProt

O95388 (UniProt - Evidence at protein level)

neXtProt

NX_O95388

Antibodypedia

WISP1 antibodies
 

PROTEIN VIEW

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WISP1-001
 
WISP1-002
 
WISP1-003
 
WISP1-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

WISP1-001 ENSP00000250160
ENST00000250160
O95388
Show all »
Show » Show » 367 40.3 Yes 0
WISP1-002 ENSP00000220856
ENST00000220856
O95388
Show all »
Show » Show » 280 30.7 Yes 0
WISP1-003 ENSP00000429185
ENST00000519433
O95388
Show all »
Show » Show » 122 13.5 Yes 0
WISP1-005 ENSP00000427744
ENST00000517423
O95388
Show all »
Show » Show » 155 16.8 Yes 0