QPRT

GENE INFORMATION

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Gene name

QPRT (HGNC Symbol)

Synonyms

QPRTase

Description

Quinolinate phosphoribosyltransferase (HGNC Symbol)

Entrez gene summary

This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

p11.2

Chromosome location (bp)

29679008 - 29698699

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000103485 (version 78.38)

Entrez gene

23475

UniProt

Q15274 (UniProt - Evidence at protein level)

neXtProt

NX_Q15274

Antibodypedia

QPRT antibodies
 

PROTEIN VIEW

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QPRT-001
 
QPRT-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

QPRT-001 ENSP00000378782
ENST00000395384
Q15274
Show all »
Show » Show » 297 30.8 Yes 0
QPRT-002 ENSP00000455183
ENST00000562473
H3BP73
Show all »
Show » Show » 149 15.7 Yes 0