UBE2I - Gene info - The Human Protein Atlas

Gene name

UBE2I (HGNC Symbol)

Synonyms

UBC9

Description

Ubiquitin-conjugating enzyme E2I (HGNC Symbol)

Entrez gene summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

p13.3

Chromosome location (bp)

1308880 - 1327018

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000103275 (version 78.38)

Entrez gene

7329

UniProt

P63279 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UBE2I-001

ENSP00000380649
ENST00000397514

P63279
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P63279 [Direct mapping]
SUMO-conjugating enzyme UBC9
H3BQQ9 [Target identity:86%; Query identity:100%]
SUMO-conjugating enzyme UBC9 {ECO:0000313|Ensembl:ENSP00000455893}
H3BRD1 [Target identity:18%; Query identity:100%]
SUMO-conjugating enzyme UBC9 {ECO:0000313|Ensembl:ENSP00000456188}

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Transporters
Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000795 [synaptonemal complex]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO ligase activity]
GO:0019899 [enzyme binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0071535 [RING-like zinc finger domain binding]

158

UBE2I-002

ENSP00000348056
ENST00000355803

P63279
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000795 [synaptonemal complex]
GO:0001650 [fibrillar center]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0008022 [protein C-terminus binding]
GO:0008134 [transcription factor binding]
GO:0010469 [regulation of receptor activity]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO ligase activity]
GO:0019899 [enzyme binding]
GO:0030425 [dendrite]
GO:0033145 [positive regulation of intracellular steroid hormone receptor signaling pathway]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043398 [HLH domain binding]
GO:0043425 [bHLH transcription factor binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045202 [synapse]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0071535 [RING-like zinc finger domain binding]

158

UBE2I-003

ENSP00000324897
ENST00000325437

P63279
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158

UBE2I-004

ENSP00000380650
ENST00000397515

P63279
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158

UBE2I-006

ENSP00000384361
ENST00000402301

B0QYN7
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B0QYN7 [Target identity:100%; Query identity:100%]
SUMO-conjugating enzyme UBC9 {ECO:0000313|Ensembl:ENSP00000384361}
H3BQQ9 [Target identity:74%; Query identity:100%]
SUMO-conjugating enzyme UBC9 {ECO:0000313|Ensembl:ENSP00000455893}
H3BRD1 [Target identity:15%; Query identity:100%]
SUMO-conjugating enzyme UBC9 {ECO:0000313|Ensembl:ENSP00000456188}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0019789 [SUMO ligase activity]

184

20.5

UBE2I-007

ENSP00000385009
ENST00000403747

P63279
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158

UBE2I-008

ENSP00000384568
ENST00000406620

P63279
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158

UBE2I-012

ENSP00000456188
ENST00000567383

H3BRD1
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H3BRD1 [Target identity:100%; Query identity:100%]
SUMO-conjugating enzyme UBC9 {ECO:0000313|Ensembl:ENSP00000456188}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

3.3

UBE2I-014

ENSP00000457064
ENST00000566587

P63279
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158

UBE2I-016

ENSP00000455893
ENST00000567074

H3BQQ9
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H3BQQ9 [Target identity:100%; Query identity:100%]
SUMO-conjugating enzyme UBC9 {ECO:0000313|Ensembl:ENSP00000455893}
H3BRD1 [Target identity:21%; Query identity:100%]
SUMO-conjugating enzyme UBC9 {ECO:0000313|Ensembl:ENSP00000456188}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005737 [cytoplasm]

137

15.5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.